Postdoctoral Fellow in computational modelling of NeuroImmune Mechanisms of Neurodegeneration ([...]

ONE NUCLEUS; Cambridge; Hybrid; GBP 40,000 - 60,000; Full time

Job summary

A leading research institution is seeking a Postdoctoral Fellow for the NeuroImmune Open Targets project. The role involves analyzing complex datasets from neurodegenerative diseases like Alzheimer's and Parkinson's while contributing to high-impact research publications. Candidates should have a PhD and strong computational skills, with financial benefits and a supportive work environment.

Benefits

Generous stipend reviewed yearly

Hybrid working arrangements

Private medical insurance

30 days annual leave plus bank holidays

Relocation package

On-site nursery

Family benefits

Qualifications

• PhD required with experience in computational research.
• Hands-on experience with single-cell and spatial data analysis workflows.
• Track record of publications as (co)first author.

Responsibilities

• Analyze large-scale single-cell datasets to identify pathological features.
• Build statistical and machine-learning methods for cell-cell signaling networks.
• Write results for publications and present at conferences.

Skills

Statistical modelling

Data analysis

Coding proficiency in R and Python

Science communication

Education

PhD in a relevant field

Job description

As a Postdoctoral Fellow on the NeuroImmune Open Targets project, you will develop and apply integrative computational pipelines to dissect immune-cell phenotypes and cell–cell interactions across Alzheimer’s, Parkinson’s, and Amyotrophic lateral sclerosis patient tissues and matched induced pluripotent stem cells models.

Your group

Saez-Rodriguez Research Group in collaboration with Open-Targets

You will

- Analyze large-scale single-cell and spatial transcriptomics datasets from human brain samples to identify shared multi-cellular pathological features

- Build and apply statistical and machine-learning methods to infer cell-cell signaling networks and causal drivers

- Develop pipelines to compare patient-derived data with hiPSC-derived models, identifying recapitulated phenotypes and candidate intervention targets

- Write up results for high-impact publications and present at international conferences

- Contribute to collaborative grant proposals and supervise junior team members

You have

- PhD in a relevant field with evidence of productive computational research

- Hands-on experience with single-cell and spatial data analysis workflows

- Strong statistical modelling and coding proficiency in R and/or Python

- Ability to translate complex computational results into biological insights

- A track record of (co)first-author publications and effective science communication

You may also have

- Demonstrated experience with single-cell and/or spatial transcriptomics data analysis

- Experience with network biology computational tools

- Knowledge of immunology, especially microglial and T-cell biology

- Background in neurodegenerative disease biology (e.g., AD, PD, ALS) and/or familiarity with polygenic risk score analyses or rare-variant genetics would also be useful

Benefits and Contract Information

- Financial incentives: depending on circumstances, monthly family/marriage allowance of £272, monthly child allowance of £328 per child. Generous stipend reviewed yearly, pension scheme, death benefit, long-term care, accident-at-work and unemployment insurances
- Hybrid working arrangements
- Private medical insurance for you and your immediate family (including all prescriptions and generous dental & optical cover)
- Generous time off: 30 days annual leave per year, in addition to eight bank holidays
- Relocation package
- Campus life: Free shuttle bus to and from work, on-site library, subsidised on-site gym and cafeteria, casual dress code, extensive sports and social club activities (on campus and remotely)
- Family benefits: On-site nursery, child sick leave, generous parental leave, holiday clubs on campus and monthly family and child allowances
- Contract duration: This position is a 2 year fixed term contract with possibility for renewal to a maximum of 5 years
- Salary: Year 1 Stipend at rate of £3,307 per month after tax (Total package will be dependant on family circumstances)
- International applicants: We recruit internationally and successful candidates are offered visa exemptions. Read more on our page for international applicants.
- Diversity and inclusion: At EMBL-EBI, we strongly believe that inclusive and diverse teams benefit from higher levels of innovation and creative thought. We encourage applications from women, LGBTQ+ and individuals from all nationalities.
- Job location: This role is based in Hinxton, near Cambridge, UK. You will be required to relocate if you are based overseas and you will receive a generous relocation package to support you.

Application Instructions:

Please submit before the closing date 20/07/2025:

1. A tailored cover letter highlighting your fit to the project and pointing to your code repository (e.g., GitHub)

2. Your CV with a list of publications

3. Contact details for three referees

Application Closing Date:

20 July 2025

Year 1 Stipend at rate of £3,307 per month after tax