Postdoctoral Fellow – Chromosome Segregation Laboratory

The Francis Crick Institute; London; On-site; GBP 43,000 - 60,000; Full time

Job summary

An established industry player is seeking a Postdoctoral Fellow in the Chromosome Segregation Laboratory. This exciting role involves investigating molecular mechanisms of chromosome segregation using advanced techniques. You will lead your own projects while collaborating with a dynamic team, contributing to groundbreaking research in cell division. The institute fosters a collaborative culture and provides access to cutting-edge technology, making it an ideal environment for innovative thinkers. If you are passionate about advancing scientific knowledge and making a difference in biomedical research, this opportunity is perfect for you.

Benefits

Health Insurance

Professional Development Opportunities

Flexible Working Hours

Access to State-of-the-Art Technology

Qualifications

• PhD in relevant field or nearing completion required.
• Experience in chromosome biology and protein analysis is essential.

Responsibilities

• Lead independent projects and collaborate with internal and external teams.
• Guide undergraduate or PhD students in their research.

Skills

Molecular Cell Biology

Biochemistry

Biophysics

Protein Purification and Analysis

Data Presentation

Education

PhD in Molecular Cell Biology

PhD in Biochemistry

PhD in Biophysics

Tools

Microscopic Techniques

Quantitative Biochemistry

Job description

Postdoctoral Fellow – Chromosome Segregation Laboratory

Postdoctoral Fellow – Chromosome Segregation Laboratory

Apply locations London time type Full time posted on Posted 5 Days Ago job requisition id R2020

Salary for this Role:

From £43,210 with benefits, subject to skills and experience

Job Title:

Postdoctoral Fellow – Chromosome Segregation Laboratory

Reports to:

Frank Uhlmann

Closing Date:

31/Jan/2025 23.59 GMT

Job Description:

Postdoc Job Description

Job title: Postdoctoral Fellow – Chromosome Segregation Laboratory

Reporting to: F Uhlmann

Contact term: This is a full-time, four-year position on Crick terms and conditions of employment.

Salary for this Role: From £43,210 with benefits, subject to skills and experience

Closing date and time: 31 January 2025

The Research Group

In the Chromosome Segregation Laboratory, we investigate molecular mechanisms that underpin faithful chromosome segregation during cell division. We use yeast and other eukaryotic model systems to study the contribution of structural chromosomal proteins to sister chromatid cohesion and chromosome condensation, essential processes that ensure faithful segregation of centimetre-long chromosomal DNA molecules within micrometre-sized cells. We also investigate how kinases and phosphatases of the cell cycle control network orchestrate the ordered progression through the successive stages of genome duplication and chromosome segregation.

Further information about us and our research can be found at this link. Research techniques used in the laboratory include but are not limited to molecular biology, genomics, biochemistry, structural biology, and biophysics.

The Project

The purpose of this role is to advance our molecular understanding of how members of the Structural Maintenance of Chromosome (SMC) family of protein complexes, cohesin and condensin, work as small molecular machines that give chromosomes their shape. In this project, some of the specific aims include but are not limited to coming to a comparative quantitative understanding of how cohesin and condensin perform their respective functions.

Postdoctoral Fellows will lead their own projects, contribute to other projects on a collaborative basis, both within the laboratory, as well as with internal and external collaborators, and they may guide undergraduate or PhD students in their research. The ability to work in a team is essential.

Key experience and competencies

The post holder should embody and demonstrate our Crick core values: Bold; Open; Collegial

Essential

• PhD in molecular cell biology, biochemistry or biophysics, or in the final stages of PhD submission
• Good knowledge of and experience in an area of chromosome biology
• Technical expertise in protein purification and analysis
• Track record of writing papers as evidenced by publications or submitted manuscripts in peer-reviewed journals
• Evidence of data presentation at scientific meetings

Desirable

• Experience in research with a model biological system
• Experience in quantitative biochemistry and biophysics
• Experience with advanced microscopic techniques

About Us

At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture, and are outward-looking, reflecting our status as a partnership of six organisations aiming to pool knowledge, ideas and resources.

We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.

If you are interested in applying for this role, please apply via our website. The closing date for applications is 31 January 2025.

All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

If you require a visa to work in the UK, we will help support your application should you be selected.

Equality, Diversity & Inclusion

The Francis Crick Institute welcomes applications from all backgrounds. We are committed to providing equal employment opportunities and recognise the positive value of diversity.

We particularly welcome applications from people who are ethnic minorities/minority ethnic as they are currently underrepresented at the Crick.

Diversity is essential to excellence in scientific endeavour. It increases breadth and perspective, leading to more innovation and creativity. We want the Crick to be a place where everyone feels valued and where diversity is celebrated and seen as part of the foundation for our Institute’s success.

The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity. We all share in the responsibility to actively promote dignity, respect, inclusivity and equal treatment.

The Francis Crick Institute is a biomedical discovery institute researching the biology underlying human health.

At the Crick, scientists and staff collaborate to stretch the very limits of what we know about how life works. Our work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections and neurodegenerative diseases.

The Francis Crick Institute is a charity, founded by the Medical Research Council, Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.