Postdoctoral Fellow – [C Swanton] Cancer Evolution and Genome Instability Laboratory

The Francis Crick Institute; London; On-site; GBP 44,000; Full time

Job summary

An established industry player in biomedical research is seeking a Postdoctoral Fellow to join their Cancer Evolution and Genome Instability Laboratory. This full-time role offers an exciting opportunity to explore the complexities of lung cancer and its treatment through innovative research. The ideal candidate will contribute to groundbreaking studies, collaborate with experts, and lead their own projects while guiding PhD students. With a commitment to fostering a diverse and inclusive environment, this role promises not only professional growth but also the chance to make a significant impact in the field of cancer research. If you are passionate about advancing scientific knowledge and eager to tackle pressing health challenges, this opportunity is perfect for you.

Benefits

Comprehensive Benefits Package

Support for Visa Applications

Access to State-of-the-Art Technology

Qualifications

• PhD or nearing completion in cancer biology or relevant field required.
• Experience in cancer biology and animal work is essential.

Responsibilities

• Drive research projects using experimental and computational approaches.
• Collaborate with a multi-disciplinary team and disseminate findings.

Skills

Cancer Biology

Cancer Immunology

Lung Stem Cell Biology

Animal Work Experience

Technical Expertise in Mouse Models

Flow Cytometry

Organizational Skills

Communication Skills

Education

PhD in Cancer Biology or related discipline

Tools

Functional In Vitro Assays

Tissue Histology

CRISPR

RNAi

Job description

Postdoctoral Fellow – [C Swanton] Cancer Evolution and Genome Instability Laboratory

Apply locations London time type Full time posted on Posted 5 Days Ago job requisition id R2013

Salary for this Role:

£43,210 with benefits, subject to skills and experience.

Job Title:

Postdoctoral Fellow – [C Swanton] Cancer Evolution and Genome Instability Laboratory

Reports to:

Charles Swanton [C]

Closing Date:

19/Jan/2025 23.59 GMT

Job Description:

Job title: Postdoctoral Fellow – [C Swanton] Cancer Evolution and Genome Instability Laboratory

Reporting to: Charles Swanton, Principal Investigator

Contract term: This is a full-time 4 years position on Crick terms and conditions of employment.

Salary for this Role: £43,210 with benefits, subject to skills and experience

The Research Group

The Cancer Evolution and Genome Instability lab studies how cancers evolve in the body to spread and become resistant to therapy and finding new ways to treat them more effectively.

This diversity, known as heterogeneity, occurs through evolutionary processes as the cells pick up DNA changes (mutations or chromosomal rearrangements) that allow them to respond and adapt to changes in the environment around them.

The Project

Lung cancer remains one of the most pressing public health concerns worldwide. Our research presents two distinct yet intertwined project directions for a postdoc candidate. We are seeking applications from candidates with a broad range of competencies.

The first research direction investigates the role of non-mutagenic carcinogens in lung cancer initiation. Recent studies have shown that most carcinogens do not solely rely on DNA mutations to drive cancer development. Our research has revealed how airborne particulate matter measuring 2.5 micrometers (PM2.5) contributes to lung cancer in never-smokers through an inflammatory axis.

The second research direction focuses on the impact of clonal hematopoiesis of indeterminate potential (CHIP)—the age-related acquisition of somatic mutations in hematopoietic stem cells—on lung cancer progression.

The postholder will be responsible for:

• Working within the multi-disciplinary team of clinicians, bioinformaticians, and bench scientists in the Swanton lab, and collaborating with groups at the Francis Crick Institute and beyond.
• Driving the project forward using relevant experimental and/or computational approaches.
• Keeping up to date with the relevant literature in the field of cancer biology.
• Attending and reporting research results at regular group meetings.
• Contributing to the dissemination of scientific results by means of writing papers for publication and presenting orally and in poster form at national and international meetings.

Postdoctoral Fellows will lead their own projects and may guide PhD students in their research. The ability to work in a team is essential.

Key experience and competencies

The post holder should embody and demonstrate our core Crick values:

Bold; Imaginative; Open; Dynamic; Collegial

Essential

• PhD, or in the final stages of PhD completion in cancer biology / cancer immunology / lung stem cell biology or other relevant discipline.
• Good knowledge and experience in cancer biology / cancer immunology / myeloid inflammation / lung stem cell biology.
• Animal work experience.
• Technical expertise in mouse models of cancer, functional in vitro assays, tissue histology, and flow cytometry approaches.
• Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals.
• Evidence of data presentation at scientific meetings.
• Excellent organisational and communication skills.
• Ability to work independently and within a team.

Desirable

• Experience in organoid culture.
• Experience in performing experiments using primary human cells and tissues.
• Experience in generating complex transgenic mouse models.
• Experience in integrative multi-omic analyses.
• Experience in performing in vivo screens using CRISPR or RNAi.

About Us

At the Crick, we conduct research at the forefront of biomedical research. We combine rigour with an open and collaborative culture.

We aim to attract the most talented researchers and support them to tackle innovative research questions. Our science technology platforms provide our researchers with access to state-of-the-art technology and expertise.

• If you are interested in applying for this role, please apply via our website.
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
• If you require a visa to work in the UK we will help support your application should you be successful.

Find out what benefits the Crick has to offer:

For more information on our great pay and benefits package please click here: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/pay-and-benefits

Equality, Diversity & Inclusion:

We welcome applications from all backgrounds. We are committed to providing equal employment opportunities.

Diversity is essential to excellence in scientific endeavour. We want the Crick to be a place where everyone feels valued.

The Crick is committed to creating equality of opportunity and promoting diversity and inclusivity.

Read more on our website: https://www.crick.ac.uk/careers-and-study/life-at-the-crick/equality-diversity-and-inclusion