Postdoc: In-Situ Macromolecular Imaging & Reconstruction

Rosalind Franklin Institute; Southmoor; On-site; GBP 42,000 - 52,000; Full time

Job summary

The Rosalind Franklin Institute seeks a motivated postdoctoral research associate to develop methods for reconstructing macromolecular structures from in-situ cryo-electron tomography data, focusing on cytoskeletal and mitochondrial changes during aging and disease.

You will work within the Grange group, coordinating specimen acquisition and developing structure-determination pipelines, in collaboration with Imperial, UCL and Oxford to map macromolecular diversity in human tissues.

Responsibilities

• Develop and streamline computational approaches to in-situ structure determination methods from tissue sources that enable an assessment of macromolecular diversity.
• Demonstrate leadership as part of a team working with clinicians to prepare tissues for cryo-electron tomography.
• Plan and conduct experiments, analyse and interpret results and supervised delivery of outputs (research reports, patent applications) in a scientific/technology area of interest.
• Work within a project team, contributing to wider projects around key Franklin's Challenges.
• Lead major contributions to research outputs including papers, patents and both internal and external presentations.
• Support and develop others including day-to-day supervision of students or visitors in areas related to your own research.
• Have supervised, staged progression to first stages of scientific independence with opportunities to further develop science and skills/experience.
• Enhance your research through collaboration with other researchers and make active contributions to exchange of ideas through your own network.
• Be able to understand, interpret, create and communicate appropriately within a research context.
• Develop search and discovery skills and techniques.
• Be supervised by a Scientist/Senior Scientist in delivery of research outputs, either in the context of a project or Franklin's Challenge or as an early career development fellow.

Job description

The Rosalind Franklin Institute seeks a motivated postdoctoral research associate to develop methods for reconstructing macromolecular structures from in-situ cryo-electron tomography data, focusing on cytoskeletal and mitochondrial changes during aging and disease.

You will work within the Grange group, coordinating specimen acquisition and developing structure-determination pipelines, in collaboration with Imperial, UCL and Oxford to map macromolecular diversity in human tissues.