Post-doctoral Research Associate in Cardiovascular Research

King's College London; London; On-site; GBP 30,000 - 40,000; Full time

Job summary

A prestigious university in London is seeking a motivated Postdoctoral Research Associate to explore cardiovascular health mechanisms and develop new therapies for heart failure. The role involves leading research projects and conducting translational studies using advanced in vivo models. Candidates should have a PhD in a relevant discipline and expertise in preclinical models. This full-time position includes a fixed term contract until September 2028 and offers an inclusive work environment with professional development opportunities.

Benefits

Professional development opportunities

Access to world-class facilities

Qualifications

• PhD in cardiovascular biology, physiology, or a related discipline.
• Expertise in preclinical mouse models of cardiovascular disease.
• Expertise in breeding and characterising transgenic mice.
• Tissue/cell culture experience.
• Broad cell/tissue biology experience.

Responsibilities

• Lead research projects investigating strategies to combat heart failure.
• Conduct translational studies for new therapeutic strategies.
• Integrate studies using isolated cell systems and advanced in vivo models.

Skills

Preclinical mouse models of cardiovascular disease

Breeding and characterising transgenic mice

Tissue/cell culture

Immunoblotting

qPCR

Teamwork

Education

PhD in cardiovascular biology, physiology, or related discipline

Job description

About Us

The School of Cardiovascular and Metabolic Medicine & Sciences (SCMMS) provides an outstanding multi-disciplinary environment for the pursuit of cutting-edge cardiovascular and metabolic research. We study the fundamental molecular, cellular, and physiological processes that underlie normal and abnormal cardiovascular and metabolic function, and drive the translation of this strong basic science into advances in clinical practice. Our research focuses on four main Themes (Cardiac, Vascular, Cardiometabolic, Diabetes & Obesity), with two cross-cutting Themes (Basic and Clinical). The School is led by Professor Mauro Giacca and comprises over 65 clinical and non-clinical academic groups, hosting 400 personnel and 110 PhD students. Our community of world-renowned researchers and educators have access to state-of-the art core facilities and expertise, including facilities for high-throughput screening and high content imaging, multimodality in vivo imaging, proteomics, integrative physiology and viral & non-viral vector production. The School activities are carried out at three main locations: James Black Centre in Denmark Hill, St Thomas's Hospital and Franklin-Wilkins Building in South Bank and the Hodgkin Building and New Hunt House/Randal Centre in Guy's Campus. As part of King's Health Partners, we have an excellent environment for basic-clinical interaction and a strong focus on mentoring and career development. The School hosts the British Heart Foundation Centre of Research Excellence at King's, which brings together a unique range of internationally recognised scientists and clinicians from across the School and King's College London.

More information: https://www.kcl.ac.uk/scmms

About The Role

We are seeking a highly motivated and talented Postdoctoral Research Associate to join Dr Joseph Burgoyne's group at the Rayne Institute, St Thomas' Hospital, part of King's College London. Our research is dedicated to uncovering the fundamental mechanisms that maintain cardiovascular health and drive cardiovascular disease, with the ultimate aim of identifying and developing new therapeutic strategies.

The successful candidate will lead research projects investigating novel strategies, discovered within our group, to combat heart failure. The work will integrate studies using isolated cell systems with advanced in vivo models, with a particular focus on characterising newly generated transgenic mouse lines. A key aspect of the work will be translational studies to evaluate new therapeutic strategies identified within our group, directly advancing our understanding of heart failure and accelerating the development of novel interventions.

Applicants must hold a PhD in a biological sciences discipline and demonstrate substantial experience working with animal models of cardiovascular disease, along with strong skills in cell and tissue biology techniques. Additional expertise in vessel myography or redox biology is highly desirable.

Joining our team offers an opportunity to work in an inclusive, dynamic and collaborative environment at the forefront of cardiovascular research, with access to world-class facilities and the opportunity to make a real difference in the development of future heart failure treatments.

This is a full-time post (35 hours per week), and you will be offered a fixed term contract until 30th September 2028.

Research staff at King's are entitled to at least 10 days per year (pro-rata) for professional development. This entitlement, from the C oncordat to Support the Career Development of Researchers , applies to Postdocs, Research Assistants, Research and Teaching Technicians, Teaching Fellows and AEP equivalent up to and including grade 7.

Visit the Centre for Research Staff Development for more information.

About You

To be successful in this role, we are looking for candidates to have the following skills and experience:

Essential criteria

1. PhD in cardiovascular biology, physiology, or a related discipline.
2. Expertise in preclinical mouse models of cardiovascular disease.
3. Expertise in breeding and characterising transgenic mice.
4. Tissue/cell culture experience.
5. Broad cell/tissue biology experience, e.g. immunoblotting, primary cell culture, qPCR, and related techniques.
6. Motivated and hard-working.
7. Ability to integrate with colleagues, work as part of a team and undertake share of group tasks.
8. Able to carry out learnt techniques unsupervised.
9. Able to plan and prioritise workload and keep clear and well-organised laboratory notes and records.

Desirable criteria

1. Expertise in vessel myography
2. Expertise in models of heart failure
3. Expertise in redox biology

Downloading a copy of our Job Description

Full details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the page. This document will provide information of what criteria will be assessed at each stage of the recruitment process.

Further Information

We pride ourselves on being inclusive and welcoming. We embrace diversity and want everyone to feel that they belong and are connected to others in our community.

We are committed to working with our staff and unions on these and other issues, to continue to support our people and to develop a diverse and inclusive culture at King's.

As part of this commitment to equality, diversity and inclusion and through this appointment process, it is our aim to develop candidate pools that include applicants from all backgrounds and communities.

We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the advert. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible.

To find out how our managers will review your application, please take a look at our ' How we Recruit ' pages.