Pioneering Medicines: Senior Research Associate/Associate Scientist, Translational Research

Futureshaper.com; Cambridge; On-site; GBP 35,000 - 50,000; Full time

Job summary

A leading biotechnology company in Cambridge is looking for a Senior Research Associate/Associate Scientist to support translational research activities. The role involves delivering data for drug discovery and collaborating with diverse teams to advance innovative treatments. Ideal candidates will have a strong background in biology or pharmacology, excellent communication skills, and a passion for scientific research.

Qualifications

• Minimum 2 years’ experience in a laboratory of academia or industry.
• Experience with ex-vivo assay development in rodent and human tissues.

Responsibilities

• Deliver impactful datasets to inform drug discovery programs.
• Collaborate on capability building to support translational needs.

Skills

Collaboration

Communication

Organizational Skills

Data Analysis

Education

Bachelor or Master of Science degree in biology, immunology, pharmacology

Tools

GraphPad PRISM

FACS

qPCR

Job description

What if... We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?

Pioneering Medicines is dedicated to conceiving and developing a broad portfolio of life-changing treatments by leveraging and expanding the use of Flagship’s multiple bioplatforms and Flagship’s proprietary innovation process. By harnessing the power of Flagship’s first-in-category platforms, Pioneering Medicines creates and advances novel medicines, partnering with Flagship companies to accelerate the extension of their portfolios into new areas and show that the platform can be applied more broadly, thereby delivering benefits to more patients, sooner.
With a highly experienced drug development team and access to the wide ecosystem of Flagship companies, Pioneering Medicines is well positioned to conceive new medicine ideas both internally and in collaboration with strategic partners and advance these assets through to significant value inflection. Pioneering Medicines currently has 11 programs ongoing with plans to have more than 15 programs in 2024. Pioneering Medicines works with external strategic partners including Novo Nordisk, Pfizer, and the Cystic Fibrosis Foundation and continues to engage in discussions on potential partnerships.

Position Summary:

What if...We could harness the power of Flagship’s scientific platforms and create novel treatment options that benefit more patients, sooner?

Pioneering Medicinesis dedicated to conceiving and developing a broad portfolio of life-changing treatments by leveraging and expanding the use of Flagship’s multiple bioplatforms and Flagship’s proprietary innovation process. By harnessing the power of Flagship’s first-in-category platforms, Pioneering Medicines creates and advances novel medicines, partnering with Flagship companies to accelerate the extension of their portfolios into new areas and show that the platform can be applied more broadly, thereby delivering benefits to more patients, sooner.

With a highly experienced drug development team and access to the wide ecosystem of Flagship companies, Pioneering Medicines is well positioned to conceive new medicine ideas both internally and in collaboration with strategic partners and advance these assets through to significant value inflection. Pioneering Medicines currently has 18 programs ongoing with plans to have more added in 2025. Pioneering Medicines works with external strategic partners including Novo Nordisk, Pfizer, and the Cystic Fibrosis Foundation and continues to engage in discussions on potential partnerships.

About Flagship Pioneering:

Flagship Pioneering is a biotechnology company that invents and builds platform companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps. Those big leaps in human health and sustainability exponentially accelerate scientific progress in areas ranging from cancer detection and treatment to nature-positive agriculture.What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our scientific founders, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and transform for the benefit of people and planet.Many companies that Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Position Summary:

Pioneering Medicines is seeking an innovative, motivated, and highly collaborative Senior Research Associate/ Associate Scientist to join our Translational Sciences team. The position supports translational research activities aimed at bridging the gap between early research and clinical development. This role will be directly accountable on data delivery to support the deep characterization of novel and emerging drug candidates, and/or execution of biomarker assays to evaluate pharmacology of therapeutic molecules. The candidate will be supported by scientific leaders to develop experience and expertise in drug discovery and pharmacology. We are looking for adaptive and scientifically curious individuals who embrace our core values of putting people and patients first, in an environment that encourages growth and learning.

This position is on-site in Cambridge.

Key Responsibilities:

• Deliver impactful datasets to inform the translational direction of drug discovery program(s) (e.g., pharmacodynamic biomarker discovery for disease/patient selection, inform human dose predictions, develop novel biomarker assays)
• Contribute to drug discovery programs supporting translational research goals and strategies.
• Collaborate on capability building to support translational needs and emerging program needs.
• Communicate research plans and data to colleagues with diverse scientific backgrounds.
• Maintain experimental records in an ELN
• Contribute to other prioritized activities and initiatives within the drug discovery group, aligned with team needs and personal interests.

Required Qualifications

• Bachelor or Master of Science degree in biology, immunology, pharmacology or equivalent with a minimum of 2 years’ experience in a laboratory of academia or industry. Industrial experience is preferred.
• Previous experience with ex-vivo assay development in rodent, NHP and human tissues/plasma/whole blood required
• Experience working with sterile cell culture techniques for the growth and maintenance of cell lines and primary cells (e.g. peripheral blood mononuclear cells, organoids, explant cultures)
• Prior working experience with in vitro cell based pharmacology assays using human or rodent primary cells

• Hands-on experience with isolating and manipulating primary cells to perform downstream analysis through techniques such as (but not limited to) MSD/ELISA, FACS, western blots, qPCR, histology, fluorescence microscopy)
• Experience with scientific software (e.g., GraphPad PRISM, imaging software)
• Independence in experimental design and execution, data analysis, interpretation, and presentation of in vitro/in vivo study analysis with ability to work efficiently and productively in a highly dynamic environment.
• Team player with a demonstrated ability to collaborate across disciplines.

Must be an organized and efficient multitasker with excellent ability to clearly communicate scientific data orally as well as via detailed documentation of experimental results via ELN.

Preferred Qualifications

• Preclinical research experience that supports early phase clinical studies or is directly related to the understanding of human disease/pharmacology.
• Experience with advanced cell biology techniques (organoid cultures, 3D cell culture models, iPSC manipulation) for use in pharmacology/translational research.
• Experience/understanding in the utility of bioinformatics to inform translational research directions.

Flagship Pioneering and our ecosystem companies arecommitted to equal employment opportunityregardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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