PhD Studentship: CENTA 2027-B01 Can a tree remember a drought? Understanding the mechanisms of tree memory

University of Birmingham; Birmingham; On-site; GBP 17,000 - 21,000; Full time

Benefits offered by this job

Annual stipend

Home fees

Research Training Support Grant

Job summary

The University of Birmingham invites applications for a PhD researcher to study how environmental information is recorded in tree DNA via epigenetic marks. The project links dendrochronology, ecology and epigenetics, examining DNA methylation across tree rings.

Funded through CENTA3 DLA by NERC, the studentship covers stipend, home fees, and a Research Training Support Grant. International applicants eligible up to 30% of cohort.

Qualifications

• At least a 2:1 at UK BSc level or a pass at UK MSc level or equivalent.
• Experience with epigenetics or DNA methylation is advantageous.
• Interest in tree biology and dendrochronology is desirable.

Responsibilities

• Investigate how environmental information is recorded in tree DNA through epigenetic marks.
• Compare DNA methylation across different tree rings and relate epigenetic changes to drought history.
• Contribute to integrating dendrochronology, ecology and epigenetics in trees.

Education

UK 2:1 BSc or MSc equivalent

Job description

Trees are long living, sessile organisms that represent a fundamental component of most of earth ecosystems. Being immobile during their life, trees need to efficiently adapt to changes of environment and to stresses, in order to reach maturity and reproduction.

Recent advanced in genomics studies are always more convincingly showing that environmental information can be recorded at molecular level on DNA through epigenetic marks. Epigenetics studies molecular changes of DNA (mostly DNA methylation) in response to developmental or environmental stimuli, which does not involve a change of the DNA sequence itself. These changes can be inherited during cell division and are particular stable in plants, where they represent the base of an epigenetic “memory”, which remains encoded in biological tissues and can be transmitted to progenies.

In trees, wood is produced by plant cells that lignified and die to provide physical functions such as of mechanical support, storage and water conduction. However, part of their DNA is preserved unaltered, and retains the epigenetic information encoded in the cells in the moment they died. In temperate zones, most trees produce in their wood one growth-ring each year, so that the entire period of a tree’s life remain impressed in its wood material. As wood growth is affected by environmental conditions, trees have marks of past interactions with the environment recorded into their wood as they grow, at both physical and molecular level. However, while physical propriety of tree rings is well investigated, the possible epigenetic changes associated to the residual DNA in different rings re.

This project aims to understand how trees use environmental information to adapt to a changing condition. This will be done by extracting DNA from different parts of tree rings and compare their epigenetic profiles. The PhD researcher will compare the DNA methylation from different tree rings and associate epigenetic changes to historical and ecological record of drought. This will allow to connect tree molecular and physical responses to the environment in in tree rings, creating for the first time a direct connection among dendrochronology, ecology and epigenetic data in trees.

Funding notes:

This project is offered through the CENTA3 DLA, funded by the Natural Environment Research Council (NERC).

• annual stipend
• tuition fees (at home-fee level)
• Research Training Support Grant.

Academic requirements: at least a 2:1 at UK BSc level or a pass at UK MSc level or equivalent.

International students are eligible for studentships to a maximum of 30% of the cohort. Funding does not cover any additional costs relating to moving or residing in the UK. International applicants must fulfil the University of Birmingham’s international student entry requirements, including English language.

References:

Zeng, Z., Raffaello, T., Liu, M.-X., and Asiegbu, F.O. (2018). Co-extraction of genomic DNA & total RNA from recalcitrant woody tissues for next-generation sequencing studies. Future Science OA 4, FSO309.