PhD in Peptide TFEB Activation for Neurodegeneration

Nuclear Inst; Bath, West of England; Presencial; GBP 18.000 - 20.000; Jornada completa

Descripción de la vacante

Nuclear Inst in collaboration with the University of Bath invites applications for a PhD project exploring peptides that directly activate TFEB to boost cellular waste clearance in neurodegenerative disease models. You will combine computational design, biochemistry and cell biology to pursue three linked objectives: discover TFEB-binding peptides, understand their mechanism, and test cellular recycling.

You will work across Bath and Bristol labs, training in structural analysis, NMR and

Formación

• First or upper second-class UK honours degree in an appropriate field (medical sciences, computing, mathematics or physical sciences).
• Non-UK applicants must meet the English language entry requirements.
• Training will be provided in peptide chemistry or structural biology if needed.

Responsabilidades

• Design TFEB-binding peptides using computational design and peptide libraries.
• Characterise peptide–TFEB interactions using biochemistry and biophysical methods.
• Test lead peptides in neuronal cell models for TFEB activation and autophagy markers.

Conocimientos

Peptide design

Molecular biology

Biochemistry

Structural biology

Educación

First or upper second-class UK honours degree

Herramientas

InsiliCoil

Descripción del empleo

Nuclear Inst in collaboration with the University of Bath invites applications for a PhD project exploring peptides that directly activate TFEB to boost cellular waste clearance in neurodegenerative disease models. You will combine computational design, biochemistry and cell biology to pursue three linked objectives: discover TFEB-binding peptides, understand their mechanism, and test cellular recycling.

You will work across Bath and Bristol labs, training in structural analysis, NMR and