PhD: Decoding Protein Aggregation in Neurodegenerative Diseases

Instruct-ERIC; Leeds; On-site; GBP 20,000 - 24,000; Full time

Job summary

University of Leeds in the United Kingdom invites applications for a PhD project focussed on decoding protein aggregation in neurodegenerative diseases using advanced mass spectrometry methods. The project will explore TDP-43 and α-synuclein, leveraging state-of-the-art MS and hydrogen–deuterium exchange MS to characterise structural transitions from soluble proteins to oligomers and amyloid fibrils.

Working in partnership with Waters Corporation, the student will gain access to cutting-edge

Qualifications

• Enrolled or eligible for PhD studies in chemistry, biochemistry or related field.
• Strong data analysis and experimental design skills.
• Experience with mass spectrometry is desirable.

Responsibilities

• Characterise protein aggregation using MS and HDX-MS techniques.
• Collaborate with Waters Corporation to access state-of-the-art instrumentation.
• Develop and apply advanced MS methods to study protein misfolding in neurodegenerative diseases.

Skills

Mass spectrometry

HDX-MS

Structural biology

Education

PhD in Chemistry/Biochemistry/Biology

Tools

HDX-MS instrumentation

Waters mass spectrometers

Job description

University of Leeds in the United Kingdom invites applications for a PhD project focussed on decoding protein aggregation in neurodegenerative diseases using advanced mass spectrometry methods. The project will explore TDP-43 and α-synuclein, leveraging state-of-the-art MS and hydrogen–deuterium exchange MS to characterise structural transitions from soluble proteins to oligomers and amyloid fibrils.

Working in partnership with Waters Corporation, the student will gain access to cutting-edge