mRNA Development Co-Op - Hands-On Biotech Lab Experience

Fspco Op012325; Cambridge; On-site; GBP 26,000 - 36,000; Full time

Job summary

Serif Biomedicines, Inc. seeks a co‑op to join the Chemistry, Manufacturing, and Controls (CMC) team. You will perform hands‑on benchwork with enzymatic mRNA synthesis, purification, and analytical characterization in a fast‑paced, entrepreneurial setting.

You will work alongside scientists and engineers, contributing to ongoing preclinical projects while gaining exposure to GMP‑like processes and data documentation. This is a full‑time, in‑office co‑op with a January 2027 start.

Qualifications

• Current student enrolled in a bachelor’s or master’s degree in chemical engineering, biology, biotechnology, or biochemistry.
• Familiarity with enzymatic reactions, such as in vitro transcription (IVT).
• Familiarity with HPLC and FPLC purification and instrumentation.
• Knowledge of TFF and instrumentation.
• Familiarity with nucleic acid analytics, including gel and capillary electrophoresis, and data interpretation.
• Knowledge of aseptic/RNase‑free handling and operation.
• Excellent time and project management.
• Excellent oral and written communication skills.

Responsibilities

• Synthesise and purify mRNA products for preclinical studies.
• Optimize and scale up enzymatic reactions for mRNA synthesis.
• Optimize and scale up purification workflow for nucleic acids using chromatography, filtration, and enzymatic steps to remove byproducts and endotoxin.
• Perform high‑throughput screens to optimize RNA generation via IVT and automated purification instrumentation.
• Operate and maintain lab instruments including FPLC (AKTA systems), TFF systems, and biosafety cabinets.
• Characterize mRNA drug substance using analytical techniques such as fragment analysis, UV spectroscopy, gel electrophoresis, and endotoxin measurement.
• Maintain an electronic laboratory notebook and documentation.
• Present findings at team and cross‑functional meetings.

Education

Bachelor's or Master's in Chemical Engineering, Biology, Biotechnology, or Biochemistry

Tools

HPLC

FPLC

TFF instrumentation

Nucleic acid analytics

Job description

Serif Biomedicines, Inc. seeks a co‑op to join the Chemistry, Manufacturing, and Controls (CMC) team. You will perform hands‑on benchwork with enzymatic mRNA synthesis, purification, and analytical characterization in a fast‑paced, entrepreneurial setting.

You will work alongside scientists and engineers, contributing to ongoing preclinical projects while gaining exposure to GMP‑like processes and data documentation. This is a full‑time, in‑office co‑op with a January 2027 start.