MRC Postdoctoral Research Scientist LMS 2646

Medical Research Council; London; On-site; GBP 35,000 - 55,000; Full time

Job summary

The Medical Research Council seeks a Postdoctoral Research Scientist in London to explore cancer metabolism and transporter biology. This role combines research leadership with collaboration in a vital field. Ideal candidates should hold a PhD and have experience with metabolomics and cell biology.

Qualifications

• PhD or equivalent experience in cancer metabolism, cellular metabolism, or related field required.
• Extensive wet lab experience in metabolic approaches, cell biology, or molecular biology.
• Strong publication record preferred.

Responsibilities

• Plan and carry out research in accordance with project aims.
• Write reports and submit publications to refereed journals.
• Provide guidance to staff and students.

Skills

Cancer metabolism

Cellular metabolism

Transporter biology

Metabolomics

Molecular biology

Education

PhD in cancer metabolism or related field

Tools

GC-MS

LC-MS

Job description

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MRC Postdoctoral Research Scientist LMS 2646, London

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Client:

Medical Research Council

Location:

London, United Kingdom

Job Category:

Other

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EU work permit required:

Yes

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Job Reference:

72b3fff56781

Job Views:

4

Posted:

29.06.2025

Expiry Date:

13.08.2025

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Job Description:

Overall purpose:

We are looking for a talented postdoctoral research scientist to work on a project in cancer metabolism and transporter biology in the Drug Transport and Tumour Metabolism group (headed by Louise Fets), at the MRC Laboratory of Medical Sciences (LMS) and Imperial College London.

We have interests in both cancer metabolism and pharmacology/drug distribution, with a particular focus on the role played by membrane transporters at the intersection between these two fields (Alam et al., DMM, 2023, Moncayo et al., BioRXiv, 2025). We have previously shown that transporter-dependent drug accumulation can have implications for drug response (Fets et al., Nat Chem Biol, 2018; Comms Biol, 2022). It is clear that transporters also shape metabolism, and their heterogeneous expression at both the inter-patient and intra-tumoural level can also have knock-on implications for drug response in cancer. With guidance from Dr Fets, the successful candidate will develop and lead a project that explores at the mechanistic level how transporter-driven metabolic changes influence drug response and drive drug resistance in cancer.

The ideal candidate will have a background in cancer metabolism, cellular metabolism, transporter biology and/or related fields. Prior experience in metabolomics and cancer cell biology are highly desirable. The position is available to be filled summer 2025, but the candidate is required to be in post by end of September 2025.

• To plan and carry out research in accordance with the project aims
• Take initiatives in the planning of research
• Write reports for submission to research sponsors
• Submit publications to refereed journals
• Provide guidance to staff and students
• Contribute to bids for research grants
• Conduct and plan own scientific work with appropriate supervision
• Maintain highly organised and accurate record of work
• To attend project and related research group meetings
• To interact and collaborate with group members
• Write-up and publication of work in peer-reviewed journals
• To take an active part in the academic activities of the LMS
• To attend and contribute to journal clubs and seminar presentations
• Presentation of data at national and international meetings
• To form good working relationships with other members of the group as well as internal and external collaborators
• To assist others and co-supervise students when required
/*generated inline style */ Person Specification

Overall purpose:

We are looking for a talented postdoctoral research scientist to work on a project in cancer metabolism and transporter biology in the Drug Transport and Tumour Metabolism group (headed by Louise Fets), at the MRC Laboratory of Medical Sciences (LMS) and Imperial College London.

We have interests in both cancer metabolism and pharmacology/drug distribution, with a particular focus on the role played by membrane transporters at the intersection between these two fields (Alam et al., DMM, 2023, Moncayo et al., BioRXiv, 2025). We have previously shown that transporter-dependent drug accumulation can have implications for drug response (Fets et al., Nat Chem Biol, 2018; Comms Biol, 2022). It is clear that transporters also shape metabolism, and their heterogeneous expression at both the inter-patient and intra-tumoural level can also have knock-on implications for drug response in cancer. With guidance from Dr Fets, the successful candidate will develop and lead a project that explores at the mechanistic level how transporter-driven metabolic changes influence drug response and drive drug resistance in cancer.

The ideal candidate will have a background in cancer metabolism, cellular metabolism, transporter biology and/or related fields. Prior experience in metabolomics and cancer cell biology are highly desirable. The position is available to be filled summer 2025, but the candidate is required to be in post by end of September 2025.

Main duties / key responsibilities:

To plan and carry out research in accordance with the project aims

Take initiatives in the planning of research

Write reports for submission to research sponsors

Submit publications to refereed journals

Provide guidance to staff and students

Contribute to bids for research grants

Conduct and plan own scientific work with appropriate supervision

Maintain highly organised and accurate record of work

To attend project and related research group meetings

To interact and collaborate with group members

Write-up and publication of work in peer-reviewed journals

To take an active part in the academic activities of the LMS

To attend and contribute to journal clubs and seminar presentations

Presentation of data at national and international meetings

To form good working relationships with other members of the group as well as internal and external collaborators

To assist others and co-supervise students when required

/*generated inline style */ Person Specification

Education / Qualifications / Training required (will be assessed from application form):

Essential:

A PhD (or equivalent experience) in cancer metabolism, cellular metabolism or a related biological field

Desirable:

A first-author publication, preprint, or manuscript in preparation for imminent submission

Previous work experience required (will be assessed from application form and at interview):

Essential:

Evidence that the candidate can plan and carry on a research project

Extensive wet lab experience in techniques relating to at least one of: metabolic approaches, cell biology, molecular biology

Desirable:

Expertise in GC-MS or LC-MS metabolomics, especially if in combination with stable isotope labelling

Experience immunofluorescence and live cell imaging

Interest in and proven experience of developing or implementing new techniques in the lab

Experience in handling and bioinformatics analysis of ‘omics datasets

Evidence of actively contributing to or driving scientific collaborations

Knowledge and experience (will be assessed from application form and at interview):

Essential:

Excellent written communication skills in English

A strong interest in cancer metabolism and transporter biology

Demonstration of creative approaches to problem solving

Desirable:

Strong publication record and exposure to scientific meetings

Personal Skills / Behaviours / Qualities (will be assessed at the interview):

Essential:

Ability to conduct reproducible research

Ability to conduct a detailed review of recent literature

Ability to develop and apply new concepts

Creative approach to problem-solving

Excellent verbal communication skills in English and the ability to deal with a wide range of people

Ability to organise own work with minimal supervision

Ability to prioritise own work in response to deadlines

Willingness to work as part of a team and to be open-minded and cooperative

Flexible attitude towards work

Discipline and regard for confidentiality and security at all times

Willingness to work out of normal working hours if the requirements of the project demand

Willingness to undertake any necessary training for the role

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