Membrane Protein Biochemist

CK Group; Cambridge, Cambridgeshire and Peterborough; On-site; GBP 40,000 - 80,000; Full time

Job summary

An innovative biopharma company is seeking a passionate Membrane Protein Biochemist to join their Protein Sciences division. This role offers the chance to work on cutting-edge drug discovery, focusing on expressing and purifying challenging membrane proteins. You will engage in collaborative research, utilizing advanced techniques to support drug design processes. With a state-of-the-art R&D center in Cambridge, this position provides a unique opportunity to contribute to impactful scientific advancements while enjoying competitive compensation and comprehensive benefits. If you're driven by scientific inquiry and innovation, this role is perfect for you.

Benefits

State-of-the-art R&D centre

Competitive salary

Restricted Stock Units

26 days annual leave

Employer pension contributions

Private medical insurance

Wellness benefits

Income protection

Death benefits

Qualifications

• PhD in Biochemistry, Biophysics, or related field required.
• Proven experience in membrane protein expression and purification.

Responsibilities

• Express and purify membrane proteins for biochemical studies.
• Collaborate with scientists to progress membrane protein targets.

Skills

Membrane Protein Expression

Membrane Protein Purification

Biochemical Techniques

Biophysical Techniques

In Silico Methods (AlphaFold)

Molecular Graphics Software (Pymol, Chimera)

Assay Development

Education

PhD in Biochemistry

PhD in Biophysics

Tools

Pymol

Chimera

Job description

Location:

Cambridge, Cambridgeshire, England

Functional Expertise:

Research & Development

CK Group is partnering with Nxera Pharma to recruit a Membrane Protein Biochemist for their Protein Sciences division.

This role is ideal for a scientist passionate about GPCRs and membrane protein biochemistry. It offers a unique opportunity to contribute to cutting-edge drug discovery in a collaborative and innovative environment.

Applications are welcomed from candidates with a PhD in Biochemistry, Biophysics, or related fields, with proven experience in membrane protein expression and purification.

Location:

Granta Park, Cambridge.

About the company:

Nxera Pharma (formerly Sosei Heptares) is a biopharma company leveraging technology to develop new medicines for patients with unmet needs globally. Their pipeline focuses on CNS, GI, immunology, metabolic disorders, and rare diseases, utilizing their GPCR-targeted structure-based drug discovery platform, NxWave.

Based in Cambridge, UK, Nxera has developed capabilities across discovery and translational medicine to advance multiple programs from pre-clinical to early clinical stages.

About the role:

You will focus on expressing and purifying challenging membrane proteins for biochemical, biophysical, and structural studies to support Nxera’s drug design process.

Responsibilities include:

• Expressing and purifying membrane proteins for various applications
• Designing and engineering expression constructs for mammalian and insect cells
• Optimizing protein expression and purification workflows
• Characterizing purified proteins using techniques like fSEC, DLS, SEC-MALS, DSF, FP
• Reconstituting proteins in membrane mimetics
• Assembling and purifying protein complexes
• Staying updated with scientific literature and developing new methodologies
• Presenting results effectively to teams
• Collaborating with scientists to progress membrane protein targets
• Maintaining detailed laboratory records

Skills and Experience:

• PhD in biochemistry, biophysics, or related field
• Skills in designing membrane protein constructs
• Experience in expressing proteins in mammalian and insect cells
• Expertise in purification protocols
• Understanding of structural and biophysical studies
• Proficiency in biochemical and biophysical techniques
• Ability to use in silico methods like AlphaFold
• Experience with molecular graphics software (e.g., Pymol, Chimera)
• Experience in assay development for drug discovery
• Experience with membrane protein reconstitution

What’s in it for you?

• State-of-the-art R&D centre in Cambridge
• Competitive salary with bonuses
• Eligible for Restricted Stock Units
• 26 days annual leave plus holidays
• Employer pension contributions
• Private medical insurance and wellness benefits
• Income protection and death benefits

Apply:

Applicants must have UK work entitlement. Please quote reference 131454 in all correspondence.