Lead Scientist, Cell Expression Technologies (Cambridge)

Lonza; Cambridge; On-site; Confidential; Full time

Benefits offered by this job

Competitive compensation

Benefits package

Job summary

Lonza Cambridge is seeking a Lead Scientist in Cell Expression Technologies to drive R&D on CHO-based expression platforms, including advances in molecular biology and factory-scale transfer of new technologies.

You will lead projects, mentor junior scientists, and spend approximately 80% of your time hands-on in the laboratory, delivering expression solutions for complex therapeutic proteins with high quality standards.

Qualifications

• PhD or equivalent advanced scientific qualification combined with relevant R&D experience.
• Strong practical expertise in CHO cell line engineering and mammalian expression system development.
• Hands-on experience in molecular biology, including development and manipulation of expression systems.
• Experience leading scientific projects, mentoring colleagues and contributing to technology development and transfer towards GMP manufacturing.

Responsibilities

• Lead key mammalian cell expression projects, spending approximately 80% of your time performing hands-on laboratory work and driving delivery of project goals.
• Develop and contribute to next-generation CHO-based expression hosts for production of complex therapeutic proteins, including transferring new technologies towards GMP manufacturing.
• Engineer mammalian cell lines using random and targeted integration and CRISPR-based gene editing, and develop expression vectors using state-of-the-art molecular biology techniques.
• Characterise engineered cell lines using analytical approaches (NGS, ddPCR, qPCR, flow cytometry) and advanced cell culture methods.
• Analyse, evaluate and sign off experimental data with high-quality records and communicate findings through reports.
• Collaborate with cross-functional teams and mentor junior scientists to support knowledge sharing and technology transfer.

Skills

CHO cell line engineering

Mammalian expression development

Molecular biology techniques

Data analysis & statistics

Project leadership

Education

PhD or equivalent advanced scientific qualification

Tools

CRISPR gene editing

NGS

qPCR

Flow cytometry

Job description

Lonza Cambridge is seeking a Lead Scientist in Cell Expression Technologies to drive R&D on CHO-based expression platforms, including advances in molecular biology and factory-scale transfer of new technologies.

You will lead projects, mentor junior scientists, and spend approximately 80% of your time hands-on in the laboratory, delivering expression solutions for complex therapeutic proteins with high quality standards.