Lead Clinical Trial Manager – Phase I–IV Trials

Discover International; Nottingham; On-site; GBP 65,000 - 90,000; Full time

Job summary

Discover International, partnered with a UK-based CRO, is seeking a Clinical Trial Manager to lead the operational delivery of Phase I–IV clinical trials for pharmaceutical and biotech sponsors. The role includes managing cross-functional teams and study timelines from start-up through close-out.

The successful candidate will own end-to-end trial management, line-manage CRAs/CRCs, and act as the primary sponsor contact. Knowledge of UK/EU regulations and risk-based monitoring is essential.

Qualifications

• Life sciences degree (or equivalent experience).
• Experience in clinical trial management within a CRO, pharma, or biotech setting (4+ years).
• Proven line management/mentoring experience.
• Strong knowledge of ICH-GCP, UK/EU trial regulations, and risk-based monitoring.

Responsibilities

• Own end-to-end trial management for assigned studies, ensuring delivery on time, on budget, and to quality standards.
• Line-manage CRAs/CRCs, overseeing site monitoring plans and performance.
• Serve as primary point of contact for sponsors, providing status updates and risk escalation.
• Develop and manage study budgets, timelines, and vendor/CRO oversight plans.
• Ensure inspection readiness and compliance with ICH-GCP, MHRA, and sponsor SOPs.
• Lead site selection, feasibility assessments, and study start-up activities.
• Chair internal and sponsor study team meetings.

Skills

Trial management

Line management

ICH-GCP knowledge

Budget management

Vendor management

Education

Life sciences degree

Job description

Discover International, partnered with a UK-based CRO, is seeking a Clinical Trial Manager to lead the operational delivery of Phase I–IV clinical trials for pharmaceutical and biotech sponsors. The role includes managing cross-functional teams and study timelines from start-up through close-out.

The successful candidate will own end-to-end trial management, line-manage CRAs/CRCs, and act as the primary sponsor contact. Knowledge of UK/EU regulations and risk-based monitoring is essential.