LC-MS Scientist

ZipRecruiter; Oxford; On-site; GBP 35,000 - 55,000; Full time

Job summary

An innovative analytics team is seeking an LC-MS Associate Scientist to advance the development of monoclonal antibody therapeutics. This role involves optimizing LC-MS methods and establishing a robust analytical service. You will collaborate with upstream development teams to support key characterizations and ensure data quality. The ideal candidate will have a strong background in LC-MS analysis and a passion for biologics. Join a forward-thinking organization where your expertise can make a significant impact on groundbreaking projects in the field of therapeutics.

Qualifications

• 3+ years of hands-on experience in LC-MS analysis of biologics.
• Strong understanding of assay development and CQA analysis.

Responsibilities

• Develop and optimise LC-MS assays for mAb characterisation.
• Set up and maintain a routine LC-MS service, including team training.
• Collaborate across scientific teams to ensure alignment.

Skills

LC-MS analysis

assay development

problem-solving

documentation

Education

BSc in Biochemistry

MSc in Molecular Biology

MSc in Analytical Chemistry

Tools

Waters BioAccord

Benchling

Job description

Job Description

We're hiring for an LC-MS Associate Scientist to join an innovative analytics team driving the development of next- monoclonal antibody therapeutics. If you have experience with LC-MS and a passion for advancing biologics, this could be a great opportunity to apply your skills in a forward-thinking environment.

The Role:

You’ll develop and optimise LC-MS methods (e.g., intact mass and N-released glycosylation analysis) and help establish a robust routine analytical service. Your work will support key characterisation of therapeutic monoclonal antibodies and integrate closely with upstream development teams.

Key Responsibilities:

• Develop and optimise LC-MS assays for mAb characterisation
• Set up and maintain a routine LC-MS service, including team training
• Troubleshoot instrumentation and ensure data quality
• Standardise analysis templates compatible with ELNs and ML integration
• Collaborate across scientific teams to ensure alignment
• Maintain detailed, GLP-compliant experimental records
• Contribute to SOPs, lab upkeep, and internal presentations

What We're Looking For:

• BSc or MSc in Biochemistry, Molecular Biology, Analytical Chemistry, or similar
• 3+ years’ hands-on experience in LC-MS analysis of biologics
• Strong understanding of assay development and CQA analysis
• Excellent documentation and problem-solving skills

Bonus Skills:

• Experience with Waters BioAccord and Benchling
• Exposure to high-throughput pipelines and broader mAb analytics (e.g., ELISA, qPCR)
• Familiarity with ICH guidelines and QbD principles

Location: Oxford

Salary: Competitive + benefits

Interested in learning more?

If you have strong LC-MS experience and want to work on impactful biologics projects, we’d love to hear from you. Apply now to explore the next step in your scientific career.