Head, Clinical Development

Eloxx Pharmaceuticals; Boston; On-site; GBP 111,748 - 148,998; Full time

Benefits offered by this job

Competitive salary and benefits

Equity opportunities

Mission-driven culture

Job summary

A growing healthcare company in Boston is seeking a Director to provide leadership for Phase 2 clinical trials in rare diseases like Alport Syndrome and ADPKD. The ideal candidate will have an MD with a nephrology specialty, proven Phase 2 program experience, and exceptional communication skills. This role offers a competitive salary, meaningful equity, and the chance to make a significant impact on patient care.

Qualifications

• Proven experience leading Phase 2 clinical programs; rare disease background valued.
• Hands-on, execution-oriented style.
• Personable and firm, able to build trust while driving accountability.
• Willing to work regularly on-site in the Boston area.

Responsibilities

• Provide medical and strategic leadership for Phase 2 trials in Alport Syndrome and ADPKD.
• Oversee protocol development, IND submissions, site activation, and trial execution.
• Build and strengthen relationships with treating physicians and patient advocacy organizations.

Skills

Nephrology specialty

Communication skills

Leadership

Education

MD

Job description

Overview

Eloxx Pharmaceuticals is at a critical stage of growth and patient impact. Backed by leading healthcare investors, we are advancing two Phase 2 studies in Alport Syndrome and ADPKD patients with nonsense mutations. These are rare diseases where every patient counts, and success could lead to the first approved therapies.

The Alport program is fully designed, IND cleared in the US, and pending MHRA and Ethics approvals in the UK. This study is expected to launch shortly and could provide a foundation for registration. The ADPKD program is in planning, creating a rare opportunity to build the program from the ground up.

This is a chance to get in on the ground floor of a company with momentum, take ownership of programs that truly matter, and advance therapies for patients with no treatment options.

Key Responsibilities

• Provide medical and strategic leadership for Phase 2 trials in Alport Syndrome and ADPKD.
• Oversee protocol development, IND submissions, site activation, and trial execution, with accountability for enrollment and timelines.
• Build and strengthen relationships with treating physicians, academic nephrologists, clinical geneticists, and patient advocacy organizations.
• Anticipate challenges in rare disease trials and guide the team in finding patient-centered solutions.
• Communicate clearly to internal stakeholders, investigators, regulators, advocacy groups, and investors.
• Lead cross-functionally and by example: approachable, collaborative, and determined.

Qualifications

• MD required; nephrology specialty strongly preferred.
• Proven experience leading Phase 2 clinical programs; rare disease background valued.
• Hands-on, execution-oriented style.
• Excellent communication and presentation skills.
• Personable and firm, able to build trust while driving accountability.
• Willing to work regularly on-site in the Boston area.

What We Offer

• Ground-floor opportunity to join a company at a pivotal moment.
• Competitive salary and benefits plus meaningful equity.
• A leadership role where your work could directly support approval in Alport and shape ADPKD development.
• The chance to collaborate with experienced clinicians, KOLs, and patient advocacy organizations, with strong investor backing.
• A mission-driven culture where persistence and creativity are essential — and where your work directly impacts patients’ lives.

Position details

• Seniority level: Director
• Employment type: Full-time
• Job function: Business Development and Sales