Fully-Funded PhD: Single-Cell Spatial Multi-Omics for Cancer

University of Cambridge; Cambridge; On-site; GBP 18,000 - 26,000; Full time

Job summary

The University of Cambridge invites applications for a PhD position in the Wang Group. The project focuses on interdisciplinary single-cell and spatial multi-omic approaches to uncover cancer cell vulnerabilities linked to ecDNA biology.

The successful candidate will develop methods bridging molecular biology, genomics and computation, while receiving training across optics, coding and cancer biology to suit their strengths.

Qualifications

• Undergraduate or Master's degree in biophysics, biology, physics, chemistry, bioengineering, physical chemistry, biomedical sciences, or a related discipline.
• Experience in molecular biology techniques is helpful but not required.

Responsibilities

• Develop and apply single-cell and spatial multi-omic approaches linking molecular signatures to cancer cell phenotypes.
• Build tools to link molecular mechanisms of gene regulation to cellular phenotypes in cancer cells.
• Dissect how ecDNA is organised, regulated and exploited in cancer; contribute to computational analysis.

Education

Biophysics

Biology

Physics

Chemistry

Bioengineering

Physical chemistry

Biomedical sciences

Related discipline

Tools

Python

R

MATLAB

Fluorescence microscopy

Image analysis

Sequencing analysis

Mammalian cell culture

Nucleic acid work

Immunofluorescence staining

Job description

The University of Cambridge invites applications for a PhD position in the Wang Group. The project focuses on interdisciplinary single-cell and spatial multi-omic approaches to uncover cancer cell vulnerabilities linked to ecDNA biology.

The successful candidate will develop methods bridging molecular biology, genomics and computation, while receiving training across optics, coding and cancer biology to suit their strengths.