Fully Funded PhD: Brain Transcriptomics & Protein Isoforms

University of Exeter; Exeter; On-site; GBP 20,000 - 24,000; Full time

Benefits offered by this job

Funding for fees and stipend

Job summary

University of Exeter invites a PhD student to identify and prioritise novel coding sequences from brain transcripts and determine if prioritised transcripts are translated into proteins. The project integrates bioinformatics, transcriptomics, proteomics and molecular biology in brain and blood contexts.

The student will analyse long-read datasets, validate candidates using mass spectrometry and single-molecule sequencing, and explore functional consequences of novel CDS through cell models and

Qualifications

• Interdisciplinary project combining bioinformatics, transcriptomics, proteomics and molecular biology.
• Long-read sequencing datasets analysis will be conducted.

Responsibilities

• Analyse long-read datasets and integrate transcriptomic and proteomic data.
• Validate selected candidates using mass spectrometry and single-molecule protein sequencing.
• Establish how isoforms affect protein expression, localisation, interactions and function in cell models.
• Collaborate with international partners developing methods for transcriptome-proteome analysis.

Skills

Bioinformatics

Transcriptomics

Proteomics

Molecular biology

Tools

Long-read sequencing

Job description

University of Exeter invites a PhD student to identify and prioritise novel coding sequences from brain transcripts and determine if prioritised transcripts are translated into proteins. The project integrates bioinformatics, transcriptomics, proteomics and molecular biology in brain and blood contexts.

The student will analyse long-read datasets, validate candidates using mass spectrometry and single-molecule sequencing, and explore functional consequences of novel CDS through cell models and