Early Phase CTAP Clinical Research Practitioner | Guy's and St Thomas' NHS Foundation Trust

Guys and St Thomas NHS Foundation Trust; Greater London; On-site; GBP 30,000 - 45,000; Full time

Job summary

A prominent NHS Trust in Greater London is seeking a Clinical Research Practitioner to coordinate early phase clinical trials for cystic fibrosis. The role involves working closely with various clinical and research teams, managing patient recruitment, ensuring compliance with research governance, and overseeing the data management processes. Ideal candidates should have a relevant degree and experience in clinical trials. Opportunities for professional development are offered.

Benefits

Professional development opportunities

Support for attendance at courses and conferences

Qualifications

• Experience in clinical trials and patient recruitment.
• Knowledge of GCP and research governance.
• Ability to communicate complex information effectively.

Responsibilities

• Act as primary contact for clinical colleagues to ensure smooth trial delivery.
• Independently assess and recruit patients and conduct health assessments.
• Draft and maintain study documentation and ensure compliance with research regulations.
• Oversee daily trial operations and coordinate multidisciplinary staff involvement.

Skills

Communication

Patient assessment

Data management

Education

Relevant degree in life sciences or nursing

Job description

Overview

This specialist role focuses on early phase CF trials, working alongside the existing CTAP Trial Coordinator and integrating into the local clinical and research teams to improve trial access for the CF community.

The postholder will work closely with local CF Clinical and Research Teams to coordinate and deliver early phase CF trials within the Trust; with the CTAP Trial Coordinator to ensure alignment and collaboration across early and later phase trials; with the CTAP Programme Team (Cystic Fibrosis Trust) for strategic guidance, reporting, and network-wide coordination; with Other CTAP Early Phase Centres and Affiliate Sites to facilitate referrals and share best practices; with Research & Development Departments to ensure governance and regulatory compliance; with Trial Sponsors and CROs to support trial setup, feasibility, and ongoing delivery; with Patients and Families to provide information, support, and facilitate participation in clinical trials; and with Training and Education Leads to deliver mentorship and training to CTAP centres preparing for early phase trial readiness.

Location and Team

This post is based within the Royal Brompton Cystic Fibrosis (CF) Clinical Trials Department, a multidisciplinary team of clinicians, academics, allied health professionals, and administrative staff. Led by Professors Davies, Simmonds, and colleagues, the adult and paediatric CF centres conduct internationally recognised, multicentre interventional and observational studies across all age groups. The department plays a key role in early phase research through its involvement in the CF Trust’s CTAP Early Phase Sub-Network (https://www.cysticfibrosis.org.uk/research/clinical-trials/clinical-trials-accelerator-platform), a specialist group of centres established by the Cystic Fibrosis Trust to lead early phase CF trials across the UK. With CF care advancing rapidly and new treatments emerging, access to clinical trials is increasingly vital. CTAP supports trial sponsors and CF centres in the setup and delivery of studies across a network of 20 centres, including Guy’s & St Thomas’ NHS Trust. Based near the vibrant King’s Road in Chelsea, this role offers excellent opportunities for collaboration and professional development within a dynamic clinical and research environment.

We encourage and support applicants in applicable career progression as a clinical research practitioner/research nurse including attendance at courses, seminars and conferences.

Responsibilities

Communication & Coordination

• Act as the primary contact for research teams and clinical colleagues, ensuring smooth trial delivery.
• Liaise with internal and external stakeholders, including the CTAP Programme Team, trial sponsors, and CF centres.
• Communicate complex and sensitive information to patients and carers, offering support and guidance.
• Attend site initiation visits, manage trial approvals, and report serious adverse events.
• Promote CF trials at meetings and contribute to team discussions and updates.

Patient Care & Trial Delivery

• Independently assess and recruit patients, manage study protocols, and ensure accurate data collection.
• Conduct health assessments (e.g. spirometry, ECG, sample collection) and administer study drugs.
• Maintain documentation to GCP and Trust standards, and support monitoring visits.

Policy & Service Development

• Draft and maintain study documentation (SOPs, CRFs) and support protocol development.
• Monitor recruitment and retention, addressing issues with the CTAP national team.
• Ensure compliance with research governance and relevant legislation.
• Stay updated on regulatory changes and contribute to service improvements.

Resource Management

• Support feasibility assessments and portfolio expansion.
• Coordinate CF research projects, monitor progress, and manage documentation systems.
• Identify recruitment barriers and liaise with relevant teams to resolve them.
• Manage equipment procurement and facilitate audits and inspections.

People Management

• Oversee daily trial operations and coordinate multidisciplinary staff involvement.
• Lead training and mentorship to support CTAP centres becoming ‘phase 1 ready’.
• Ensure staff are trained and delegated appropriately; support induction of new team members.

Information Management

• Use multiple data platforms to manage trial data accurately and efficiently.
• Oversee data entry, verification, and reporting; troubleshoot system and data issues.
• Manage archiving and ensure compliance with data protection and IT policies.
• Coordinate quarterly metric reporting to the CTAP Coordinating Team.

Research & Development

• Lead audits and implement improvements based on governance standards.
• Apply learning from existing studies to enhance future trial delivery.
• Collaborate with clinical teams to develop services and promote research impact.

Other Duties

• Be available for occasional night shifts and weekend cover.
• Undertake other duties appropriate to the role and grade as required.

This advert closes on Sunday 5 Oct 2025