Formulation Scientist

ZipRecruiter; Cambridge; On-site; GBP 40,000 - 55,000; Full time

Job summary

A leading gene synthesis company in Cambridge is seeking an experienced laboratory professional to join their R&D team. The role involves preparing lipid nanoparticles and developing analytical methods for gene delivery. Candidates should have a strong background in chemistry or biochemistry, with practical lab experience and excellent communication skills. The company offers a competitive salary and benefits.

Benefits

Private healthcare

Pension contributions

Life assurance

Qualifications

• Minimum 2 years practical laboratory experience.
• Experience in nanoparticle production methods.
• Knowledgeable in molecule level chemistry.

Responsibilities

• Preparation and characterisation of lipid nanoparticles.
• Development of novel assays for nanoparticle characterisation.
• Execute experiments and data analysis.

Skills

Communication

Self-motivated

Statistical data analysis

Education

BSc, MSc or PhD in Chemistry

Biochemistry

Biochemical engineering

Tools

DLS

Electron microscopy

HPLC

Job description

Job Description

4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapies and gene vaccines. The company is expanding their research and development team at our site in Cambridge, UK to facilitate the scaling of our proprietary DNA manufacturing process, further development of our non-viral platform and AAV vectors for DNA delivery. We are looking for a dynamic and experienced team member to help us achieve our ambitions and goals.

The primary focus of the role is the preparation and characterisation of lipid nanoparticles for client and collaborator projects, in addition to R&D formulation and analytical method development of 4Basebio’s non-viral delivery platform. There will be opportunity for the candidate to interact with multi-disciplinary teams within the research department and expand their laboratory skill set.

Responsibilities:

• Preparation and characterisation of lipid nanoparticles for client or collaborator projects
• R&D of non-viral delivery platform: formulation, characterisation and validation of novel nanoparticles for gene delivery based on end needs of the formulations
• Development of novel assays and analytical methods for nanoparticle characterisation
• Execute experiments and be involved in data analysis and interpretation of experimental results.
• Actively participate and contribute to laboratory and company meetings
• Maintain an accurate and complete record of laboratory work performed
• To use and maintain company equipment in accordance with the company’s SOPs and health & safety guidelines
• To undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested

Person Specification:

• Minimum 2 years practical laboratory experience in relevant scientific field
• BSc, MSc or PhD degree in Chemistry, Biochemistry, biochemical engineering or related discipline
• Experience in nanoparticle production methods (e.g. microfluidics)
• Experience in nanoparticle characterization (e.g. DLS, electron microscopy, HPLC) and downstream process (e.g. purification, sterilization, long-term storage) techniques.
• Knowledgeable and/or willingness to discuss molecule level chemistry. Molecular modelling, chemical synthesis or analytical chemistry knowledge desirable
• Experience in Design of Experiments (DoE) and statistical data analysis is desirable
• An understanding of the basics of gene therapy and nano-scale drug delivery technologies, with an interest in current global development activities and research
• Experience/knowledge on the handling of nucleic acids and related testing techniques (e.g. gel electrophoresis, nucleic acid quantification assay) is desirable
• Great communication and presentation skills
• Self-motivated and willing to learn new skills
• Ability to work in a fast-paced environment and manage multiple projects in parallel.
• Must hold the right to work in the UK.

What we can offer: Competitive salary + private healthcare + pension contributions + life assurance

Location: Over, Cambridge

To apply for this role send you CV and covering letter to [e-mail]

Due to the high number of applicants, if you do not hear back from us within 6 weeks, we thank you for your interest, but please assume you have not been selected for interview on this occasion.