CMC Consultant - LNP Delivery Systems

JR United Kingdom; United Kingdom; On-site; GBP 60,000 - 90,000; Full time

Job summary

A leading consultancy in life sciences seeks a highly experienced CMC Consultant for a project-based role focusing on Lipid Nanoparticle (LNP) delivery systems for mRNA therapeutics. The consultant will manage CDMO partnerships, provide formulation support, and ensure effective integration of mRNA into LNP platforms, requiring extensive expertise in CMC processes.

Qualifications

• Advanced degree (PhD or MSc preferred) in relevant fields.
• Extensive experience with LNP delivery systems.
• Proven track record of CMC leadership.

Responsibilities

• Assist in identifying and selecting CDMOs for LNP development.
• Provide CMC input on formulation development and manufacturing processes.
• Work closely with mRNA experts on loading and encapsulation strategies.

Skills

CMC leadership

Formulation development

LNP delivery systems

mRNA integration

CDMO management

Education

PhD or MSc in Pharmaceutical Sciences, Chemistry, Biochemistry

Job description

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CMC Consultant - LNP Delivery Systems, united kingdom

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Client:

Advanced Resource Managers

Location:

Job Category:

Other

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EU work permit required:

Yes

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Job Views:

1

Posted:

23.05.2025

Expiry Date:

07.07.2025

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Job Description:

We are seeking a highly experienced CMC Consultant to support our client, a specialist life science consultancy, in the development of Lipid Nanoparticle (LNP) delivery systems for mRNA-based therapeutics. This consultant will play a key role in identifying and managing CDMO partners, guiding formulation and manufacturing strategy, and supporting mRNA experts with integration into LNP platforms.

This is a project-based, ad-hoc contract role, ideal for a specialist with deep technical expertise in LNP systems and strong knowledge of CMC requirements for mRNA-based drug products.

Responsibilities

CDMO Identification & Oversight

• Assist the client in identifying, evaluating, and selecting CDMOs for LNP development and production.
• Define and assess technical capabilities of CDMOs in:

-Endotoxin testing

-Structure-function assessments (e.g., Zeta potential, particle size, polydispersity, etc.)

• Oversee and support CDMO relationships throughout development lifecycle.

CMC & Formulation Support

• Provide CMC input and strategic guidance on formulation development and manufacturing processes for LNP systems.
• Advise on chemistry, formulation stability, and process scalability of LNP platforms.

mRNA Integration Support

• Work closely with mRNA subject matter experts to:

-Guide loading and encapsulation strategies

-Optimise stabilisation of mRNA within LNPs

-Ensure integrity and efficiency of delivery

Requirements

• Advanced degree (PhD or MSc preferred) in Pharmaceutical Sciences, Chemistry, Biochemistry, or related field
• Extensive experience with LNP delivery systems, ideally in an mRNA therapeutic or vaccine setting
• Proven track record of CMC leadership in formulation, development, and external manufacturing
• Hands-on knowledge of critical LNP attributes such as encapsulation, zeta potential, endotoxin levels, and particle characterisation
• Experience managing or liaising with CDMOs or external partners