Development Scientist - Oligonucleotide

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Development Scientist - Oligonucleotide, Didcot

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Client:

Oxford Nanopore Technologies

Location:

Didcot, United Kingdom

Job Category:

Other

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EU work permit required:

Yes

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Job Reference:

50441786c9e0

Job Views:

10

Posted:

26.04.2025

Expiry Date:

10.06.2025

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Job Description:

Oxford Nanopore Technologies is headquartered at the Oxford Science Park outside Oxford, UK, with satellite offices and a commercial presence in many global locations across the US, APAC and Europe.

Oxford Nanopore employs from multiple subject areas including nanopore science, molecular biology and applications, informatics, engineering, electronics, manufacturing and commercialisation. The management team, led by CEO Dr Gordon Sanghera, has a track record of delivering disruptive technologies to the market.

Oxford Nanopore’s sequencing platform is the only technology that offers real-time analysis, in fully scalable formats from pocket to population scale, that can analyse native DNA or RNA and sequence any length of fragment to achieve short to ultra-long read lengths. Our goal is to enable the analysis of any living thing, by anyone, anywhere!

In this exciting and challenging role you will assist in expanding the nucleotide and oligonucleotide synthesis capabilities aimed at research and development within a newly established oligonucleotide facility.

Depending on experience, you will take on technical leadership roles and work closely with other members of the oligonucleotide facility team and develop new synthesis, purification and analytical methodologies/workflows for a wide range of critical long and modified DNA/RNA oligonucleotides.

In addition, you will play a collaborative role in the decision making of strategic objectives that influence future projects, the team and the company.

Tasks Will Include:

• Developing an oligonucleotide synthesis pipeline to serve critical R&D projects.
• Developing synthesis methodologies for complex, modified and long DNA/RNA oligonucleotides.
• Improving purification and analytical workflows for synthesised oligonucleotides, introducing automation where possible.
• Analysing oligonucleotides by high-resolution CE, LC-MS and HPLC.
• Onboarding new technology and methods to improve operational effectiveness.
• Contributing to the scientific and technical training of the team.
• Promoting a safe working environment for all team members and a culture of continuous improvement for health & safety.
• Preparing clearly articulated progress reports and keeping well-organised experimental records.
• Working and communicating effectively across a number of research and development groups
  

What We're Looking For...

• BSc, MSc or PhD degree in chemistry with industrial or equivalent experience.
• Strong experience in oligonucleotide synthesis
• Nucleosides, phosphoramidites and triphosphates synthesis experience would be a plus.
• Practical knowledge of small molecules and oligonucleotide analysis and purification.
• Strong problem solving and analytical skills.
• Strong attention to detail and a high level of organisation.
  

Training will be given and, as such, a willingness to learn and develop is essential.

Applications are encouraged from highly motivated individuals who enjoy taking on new challenges, are quickly adaptable in an exciting and fast-paced environment, and who perform well under pressure.

We offer outstanding benefits to include an attractive bonus, generous pension contributions, private healthcare and an excellent starting salary. Based within beautiful, landscaped surroundings with tree-lined walks, water features and a lake, all of which make for a wonderful working environment.

If you are looking to utilise your skills to really make a difference to humankind, then consider joining our team and apply today!