Cryo-EM Structural Biologist: Cohesin/SMC Complexes

UK-Research-and-Innovation-; Greater London; On-site; GBP 37,000 - 39,000; Full time

Job summary

The MRC Laboratory of Medical Sciences (LMS) at Imperial College London invites applications for a Research Technician – Cryo‑EM / Structural Biology in the DNA Motors group led by Professor Luis Aragon. This 12‑month fixed‑term, full‑time post is based in Hammersmith, London, and supports translational cryo‑EM work on cohesin/SMC complexes and drug discovery efforts.

You will express and purify STAG1 and related SMC complexes, prepare cryo‑EM grids, collect data, and carry out single‑particle

Qualifications

• PhD in structural biology, biochemistry or closely related field with a cryo‑EM focus (or Masters with equivalent experience)

Responsibilities

• Express and purify STAG1 and cohesin complexes for structural studies
• Prepare and screen cryo‑EM grids; collect data
• Perform single‑particle image processing and 3D reconstruction
• Determine structures of STAG1/cohesin with screening hits
• Contribute to hit validation with biochemical/biophysical assays
• Communicate structural results to guide compound design with partners
• Attend meetings and contribute to write‑ups/publications

Skills

Cryo‑EM single‑particle

STAG1/cohesin knowledge

Protein expression and purification

Data processing (RELION/cryoSPARC)

Scientific communication

Education

PhD in structural biology/biochemistry (cryo‑EM focus)

Tools

RELION

cryoSPARC

Job description

The MRC Laboratory of Medical Sciences (LMS) at Imperial College London invites applications for a Research Technician – Cryo‑EM / Structural Biology in the DNA Motors group led by Professor Luis Aragon. This 12‑month fixed‑term, full‑time post is based in Hammersmith, London, and supports translational cryo‑EM work on cohesin/SMC complexes and drug discovery efforts.

You will express and purify STAG1 and related SMC complexes, prepare cryo‑EM grids, collect data, and carry out single‑particle