CRISPR Screening Lead

JR United Kingdom; London; On-site; GBP 60,000 - 85,000; Full time

Job summary

Une entreprise de biotechnologie innovante cherche à recruter un Senior Scientist II pour diriger des campagnes de dépistage de CRISPR. Le candidat aura la responsabilité de concevoir et d'exécuter des campagnes de criblage à haut débit, apportant une expertise technique et un leadership de projet dans un environnement dynamique et collaboratif. Cette position exige des compétences prouvées en développement d'assai et plusieurs années d'expérience pratique en laboratoire.

Qualifications

• Expérience pratique de plus de 2 ans avec CRISPR à l'échelle.
• Compétences en interprétation des données et communication.
• Connaissance en développement d'essai avec des cellules endothéliales.

Responsibilities

• Diriger la conception, l'exécution et l'analyse des campagnes de dépistage.
• Développer des méthodes de livraison CRISPR basées sur la nucléofection.
• Servir de mentor technique pour les scientifiques juniors.

Skills

CRISPR

Problem-solving

Assay development

Collaboration

Education

PhD

Job description

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Job Title: Senior Scientist II – CRISPR Screening Lead

Location: London, UK (On-site, 5 days per wee- 100% Lab based

Job Type: Full-time

About the Role

We are seeking an experienced and highly motivated Principal Scientist or Senior Scientist II to lead one of our high-throughput screening (HTS) campaigns. This is a hands-on, lab-based role for a scientifically driven leader ready to take ownership of CRISPR-based functional genomics screens. The successful candidate will bring deep technical expertise and strong project leadership to drive discovery at the cutting edge of cell biology and gene editing.

Key Responsibilities

• Lead the design, execution, and analysis of high-throughput screening campaigns, with a focus on CRISPR-based perturbation in an arrayed format.
• Drive fibroblast and endothelial cell assay development to enable robust and reproducible screening platforms.
• Collaborate cross-functionally to align screening outputs with broader scientific objectives.
• Contribute to experimental planning, troubleshooting, and optimization of nucleofection-based CRISPR delivery methods.
• Serve as a technical mentor and scientific resource to more junior scientists on the team.

Required Qualifications

• Extensive hands-on experience leading multiple high-throughput screening campaigns, preferably arrayed CRISPR screens.
• Minimum 2 years of practical experience using CRISPR at scale, including nucleofection as the primary delivery method.
• Proven expertise in assay development; experience with endothelial cell assays using primary cells is essential.
• Strong problem-solving skills and ability to thrive in a fast-paced, dynamic lab environment.
• Willingness to be physically present in the lab five days a week; candidates must be based in or willing to relocate to London or a commutable distance.

Preferred Qualifications

• Prior experience leading screening teams or scientific projects.
• Strong data interpretation and communication skills.
• Experience working in collaborative, matrixed R&D teams.

Application open to all with +3 years experience post PhD in academia OR Industry