Contract Role: Scientist, DeNovo Discovery

ZipRecruiter; Cambridge; On-site; GBP 40,000 - 85,000; Full time

Job summary

Join a pioneering biopharmaceutical company focused on revolutionizing therapeutics. This role offers the chance to work on cutting-edge drug discovery projects, utilizing innovative techniques to develop assays and collaborate with a dynamic team. You will play a crucial role in optimizing the delivery of therapeutics, contributing to groundbreaking advancements in the field of precision medicine. With a commitment to patient outcomes and a collaborative environment, this opportunity is perfect for a motivated biochemist or cell biologist looking to make a significant impact in oncology and peptide drug discovery.

Qualifications

• Ph.D. or Master's with extensive experience in drug discovery.
• Strong background in liquid chromatography-mass spectrometry.

Responsibilities

• Develop assays for cellular uptake and endosomal escape of therapeutics.
• Collaborate with chemists and biologists on experimental designs.

Skills

Drug Discovery

Liquid Chromatography-Mass Spectrometry

Cell-Based Assays

Biophysical/Biochemical Assays

Oncology Knowledge

Interpersonal Skills

Communication Skills

Education

Ph.D. in Relevant Fields

Master's Degree

Tools

Mass Spectrometry

Cell Fractionation

Confocal Microscopy

Job description

Why join us?

Parabilis Medicines is a distinctive biopharmaceutical company aiming to become a leader in therapeutics. Our platform, Helicon therapeutics, involves peptides capable of efficient cell entry and modulation of protein-protein and protein-DNA interactions. This technology has the potential to revolutionize treatment options by targeting intracellular disease drivers previously considered undruggable.

Our lead program, FOG-001, is an early-stage, first-in-class TCF-blocking β-catenin inhibitor, currently in clinical trials for advanced solid tumors, including colorectal cancer. We leverage proprietary machine learning and computational methods in our discovery process. With over $500 million raised, Parabilis is headquartered in Cambridge, MA.

What’s the opportunity?

We seek a skilled biochemist/cell biologist with drug discovery experience to join our DeNovo Discovery team. The role involves developing assays to study cellular uptake and endosomal escape of our therapeutics, collaborating with chemists, biologists, and data scientists to design experiments assessing Helicon uptake, cytosolic exposure, and escape mechanisms.

You will also support efforts to identify new molecules by performing routine testing for cytosolic exposure and cellular uptake.

Key objectives include:

• Identify and refine core assays to measure and optimize cytosolic exposure of Helicons
• Develop additional assays to contextualize CE data
• Provide data-driven insights to inform drug design and structure-activity relationships
• Design cell-based functional assays using techniques like cell fractionation, mass spectrometry, and confocal microscopy

What you'll need to be successful:

• Ph.D. in relevant fields with 3+ years of experience, or Master's with 8+ years in drug discovery
• Experience with liquid chromatography-mass spectrometry
• Experience developing cell-based uptake and proximity-dependent activity assays (e.g., NanoBiT, NanoBRET) is a plus
• Knowledge of biophysical/biochemical assays (ITC, DSF, MST, FP, TR-FRET) and structural biology is advantageous
• Experience in oncology and peptide drug discovery is preferred
• Strong motivation, independence, organization, and multitasking skills
• Flexibility to adapt to changing workflows and projects
• Excellent interpersonal and communication skills

On-site work and in-person meetings are required.

Core Values

We are passionate pioneers in precision medicine, committed to fostering an inspiring, innovative environment focused on patient benefit. Our values include:

• Growth-Minded: Curious, humble, adaptable in inventing new medicines
• In(ter)dependent: Fostering independence and collaboration to challenge drug discovery paradigms
• Patient-focused: Prioritizing patient outcomes in all efforts
• All-In: Fully committed to solving scientific challenges and delivering groundbreaking therapies

Parabilis is an equal opportunity employer, valuing diversity and inclusion. We consider all qualified applicants without discrimination based on protected characteristics.

30 Acorn Park Drive | Cambridge, MA 02140 | www.parabilismed.com