Consultant Call – Preclinical pharmacology consultant (Peptide Therapeutics)

Constructive Bio; Cambridge; Remote; GBP 80,000 - 100,000; Part time

Job summary

A biotechnology firm is seeking an experienced consultant in DMPK for peptide development programs. The role involves planning in vivo and in vitro studies, advising on DMPK strategy, and analyzing data to guide project teams. Ideal candidates will have expertise in pharmacology and PK/PD modelling, along with strong communication skills. This position offers flexible consulting arrangements.

Qualifications

• Track record in DMPK for peptides or biologics.
• Experience with PK/PD modelling and half-life extension technologies.
• Ability to provide strategic guidance and hands-on analysis.

Responsibilities

• Plan and review in vivo studies including PK and bioavailability.
• Advise on overall DMPK strategy including study design and regulatory expectations.
• Analyse data and recommend next steps for project teams.

Skills

DMPK for peptides or biologics

PK/PD modelling

Communication skills

Job description

Overview

Consultant Call – DMPK (Peptide Therapeutics)

Constructive Bio is seeking an experienced DMPK or PK/PD (preclinical pharmacology) consultant to support ASAP the design and delivery of our peptide development programs. Our pipeline includes engineered peptides incorporating non-canonical amino acids, and we need expertise to translate molecular design into clear DMPK strategies and data packages. We need someone experienced available now.

Responsibilities

• Plan and review in vivo studies (PK, bioavailability, half-life, clearance routes, immunogenicity considerations).
• Plan and review in vitro assays (plasma stability, protease resistance, plasma protein binding, permeability).
• Advise on overall DMPK strategy for peptides, including study design, interpretation, and regulatory expectations.
• Analyse data, highlight risks, and recommend next steps to guide project teams.
• Benchmark against industry best practices and prepare input suitable for preclinical packages.
• Support vendor/CRO selection and study oversight.

Qualifications

• Track record in DMPK for peptides or biologics, ideally in pharma/biotech. Evidence for the track record needs to be provided.
• Experience with PK/PD modelling, half-life extension technologies, and translation from animal to human.
• Ability to work flexibly as a consultant, providing both strategic guidance and hands-on analysis.
• Strong communication skills to work with internal scientists and external partners.

Desirable

• Experience of in vitro and in vivo safety and toxicology studies
• Knowledge and preparation of IND documents would be an advantage

We are open to short- or medium-term consulting arrangements.