CMC Consultant - LNP Delivery Systems

JR United Kingdom; Wolverhampton; On-site; GBP 60,000 - 90,000; Full time

Job summary

A leading company is seeking a highly experienced CMC Consultant to support the development of Lipid Nanoparticle (LNP) delivery systems for mRNA therapeutics. This project-based role requires deep technical expertise and a strong knowledge of CMC requirements. The consultant will assist in managing CDMO partners and provide strategic guidance on formulation and processes.

Qualifications

• Advanced degree in Pharmaceutical Sciences, Chemistry, Biochemistry, or a related field required.
• Extensive experience with LNP delivery systems, especially in mRNA therapeutics.
• Proven CMC leadership track record in formulation and external manufacturing.

Responsibilities

• Assist in identifying and evaluating CDMOs for LNP development.
• Provide CMC input on formulation and manufacturing processes.
• Work with mRNA experts to optimize delivery and integrity.

Skills

LNP delivery systems

CMC leadership

Formulation development

Endotoxin testing

Zeta potential

Particle characterization

Education

PhD or MSc in Pharmaceutical Sciences

PhD or MSc in Chemistry

PhD or MSc in Biochemistry

Job description

CMC Consultant - LNP Delivery Systems, wolverhampton

Client:

Advanced Resource Managers

Location:

Job Category:

Other

-

EU work permit required:

Yes

Job Views:

4

Posted:

31.05.2025

Expiry Date:

15.07.2025

Job Description:

We are seeking a highly experienced CMC Consultant to support our client, a specialist life science consultancy, in the development of Lipid Nanoparticle (LNP) delivery systems for mRNA-based therapeutics. This consultant will play a key role in identifying and managing CDMO partners, guiding formulation and manufacturing strategy, and supporting mRNA experts with integration into LNP platforms.

This is a project-based, ad-hoc contract role, ideal for a specialist with deep technical expertise in LNP systems and strong knowledge of CMC requirements for mRNA-based drug products.

Responsibilities

CDMO Identification & Oversight

• Assist the client in identifying, evaluating, and selecting CDMOs for LNP development and production.
• Define and assess technical capabilities of CDMOs in:

-Endotoxin testing

-Structure-function assessments (e.g., Zeta potential, particle size, polydispersity, etc.)

• Oversee and support CDMO relationships throughout development lifecycle.

CMC & Formulation Support

• Provide CMC input and strategic guidance on formulation development and manufacturing processes for LNP systems.
• Advise on chemistry, formulation stability, and process scalability of LNP platforms.

mRNA Integration Support

• Work closely with mRNA subject matter experts to:

-Guide loading and encapsulation strategies

-Optimise stabilisation of mRNA within LNPs

-Ensure integrity and efficiency of delivery

Requirements

• Advanced degree (PhD or MSc preferred) in Pharmaceutical Sciences, Chemistry, Biochemistry, or related field
• Extensive experience with LNP delivery systems, ideally in an mRNA therapeutic or vaccine setting
• Proven track record of CMC leadership in formulation, development, and external manufacturing
• Hands-on knowledge of critical LNP attributes such as encapsulation, zeta potential, endotoxin levels, and particle characterisation
• Experience managing or liaising with CDMOs or external partners

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Created on 31/05/2025 by JR United Kingdom