CMC Consultant - LNP Delivery Systems

JR United Kingdom; Portsmouth; On-site; GBP 65,000 - 90,000; Full time

Job summary

A leading life science consultancy seeking a highly experienced CMC Consultant to support the development of Lipid Nanoparticle (LNP) delivery systems. The role involves guiding formulation strategies and managing relationships with CDMO partners, requiring specialized knowledge in mRNA therapeutics. Ideal candidates will have advanced degrees and extensive experience in CMC for drug products.

Qualifications

• Advanced degree in Pharmaceutical Sciences, Chemistry, or Biochemistry.
• Extensive experience with LNP delivery systems.
• Proven track record of CMC leadership in formulation and development.

Responsibilities

• Identify and manage CDMO partners for LNP development.
• Provide CMC input on formulation and manufacturing processes.
• Collaborate with mRNA experts to optimize delivery strategies.

Skills

CMC leadership

Technical expertise in LNP systems

Knowledge of CMC requirements for mRNA

Formulation development

Endotoxin testing knowledge

Education

PhD or MSc in Pharmaceutical Sciences

Degree in Chemistry/Biochemistry or related field

Job description

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CMC Consultant - LNP Delivery Systems, portsmouth, hampshire

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Client:

Advanced Resource Managers

Location:

portsmouth, hampshire, United Kingdom

Job Category:

Other

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EU work permit required:

Yes

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Job Views:

4

Posted:

31.05.2025

Expiry Date:

15.07.2025

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Job Description:

We are seeking a highly experienced CMC Consultant to support our client, a specialist life science consultancy, in the development of Lipid Nanoparticle (LNP) delivery systems for mRNA-based therapeutics. This consultant will play a key role in identifying and managing CDMO partners, guiding formulation and manufacturing strategy, and supporting mRNA experts with integration into LNP platforms.

This is a project-based, ad-hoc contract role, ideal for a specialist with deep technical expertise in LNP systems and strong knowledge of CMC requirements for mRNA-based drug products.

Responsibilities

CDMO Identification & Oversight

• Assist the client in identifying, evaluating, and selecting CDMOs for LNP development and production.
• Define and assess technical capabilities of CDMOs in:

-Endotoxin testing

-Structure-function assessments (e.g., Zeta potential, particle size, polydispersity, etc.)

• Oversee and support CDMO relationships throughout development lifecycle.

CMC & Formulation Support

• Provide CMC input and strategic guidance on formulation development and manufacturing processes for LNP systems.
• Advise on chemistry, formulation stability, and process scalability of LNP platforms.

mRNA Integration Support

• Work closely with mRNA subject matter experts to:

-Guide loading and encapsulation strategies

-Optimise stabilisation of mRNA within LNPs

-Ensure integrity and efficiency of delivery

Requirements

• Advanced degree (PhD or MSc preferred) in Pharmaceutical Sciences, Chemistry, Biochemistry, or related field
• Extensive experience with LNP delivery systems, ideally in an mRNA therapeutic or vaccine setting
• Proven track record of CMC leadership in formulation, development, and external manufacturing
• Hands-on knowledge of critical LNP attributes such as encapsulation, zeta potential, endotoxin levels, and particle characterisation
• Experience managing or liaising with CDMOs or external partners