CMC Consultant - LNP Delivery Systems

JR United Kingdom; Aberdeen City; On-site; GBP 60,000 - 90,000; Full time

Job summary

A leading life science consultancy is seeking a highly skilled CMC Consultant for an ad-hoc project role focused on lipid nanoparticle delivery systems for mRNA therapeutics. The ideal candidate will possess a PhD in a relevant field and extensive experience with LNP systems.

Qualifications

• Extensive experience with LNP delivery systems in mRNA therapeutics.
• Proven track record in CMC formulation and development.
• Hands-on knowledge of encapsulation and particle characterization.

Responsibilities

• Assist in identifying and selecting CDMOs for LNP development.
• Provide CMC input on formulation development and manufacturing processes.
• Work with mRNA experts on encapsulation strategies.

Skills

LNP delivery systems

CMC leadership

Formulation development

Education

PhD or MSc in Pharmaceutical Sciences

Job description

Client:

Advanced Resource Managers

Location:

Job Category:

Other

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-

EU work permit required:

Yes

Job Views:

4

Posted:

31.05.2025

Expiry Date:

15.07.2025

Job Description:

We are seeking a highly experienced CMC Consultant to support our client, a specialist life science consultancy, in the development of Lipid Nanoparticle (LNP) delivery systems for mRNA-based therapeutics. This consultant will play a key role in identifying and managing CDMO partners, guiding formulation and manufacturing strategy, and supporting mRNA experts with integration into LNP platforms.

This is a project-based, ad-hoc contract role, ideal for a specialist with deep technical expertise in LNP systems and strong knowledge of CMC requirements for mRNA-based drug products.

Responsibilities

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CDMO Identification & Oversight

• Assist the client in identifying, evaluating, and selecting CDMOs for LNP development and production.
• Define and assess technical capabilities of CDMOs in:

-Endotoxin testing

-Structure-function assessments (e.g., Zeta potential, particle size, polydispersity, etc.)

• Oversee and support CDMO relationships throughout development lifecycle.

CMC & Formulation Support

• Provide CMC input and strategic guidance on formulation development and manufacturing processes for LNP systems.
• Advise on chemistry, formulation stability, and process scalability of LNP platforms.

mRNA Integration Support

• Work closely with mRNA subject matter experts to:

-Guide loading and encapsulation strategies

-Optimise stabilisation of mRNA within LNPs

-Ensure integrity and efficiency of delivery

Requirements

• Advanced degree (PhD or MSc preferred) in Pharmaceutical Sciences, Chemistry, Biochemistry, or related field
• Extensive experience with LNP delivery systems, ideally in an mRNA therapeutic or vaccine setting
• Proven track record of CMC leadership in formulation, development, and external manufacturing
• Hands-on knowledge of critical LNP attributes such as encapsulation, zeta potential, endotoxin levels, and particle characterisation
• Experience managing or liaising with CDMOs or external partners

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Created on 31/05/2025 by JR United Kingdom