Biosensor Research Scientist (Electrochemical sensors)

Level Zero Health; Greater London; On-site; GBP 65,000 - 90,000; Full time

Benefits offered by this job

Equity options

Travel to New York and R&D sites

Job summary

Level Zero Health is seeking a biosensor scientist with a strong background in electrochemical biosensor R&D and aptamer work to join our London-based startup. You will design and optimize sensors, develop assays, and troubleshoot complex bioanalytical challenges.

Collaborating with chemists, biologists, and data scientists, you will translate bio-element interactions into robust sensor outputs, publish findings, and contribute to advancing our hormone-sensing platform with data-driven

Qualifications

• PhD required in Electrochemistry, Analytical Chemistry, Biochemistry, Chemical/Materials Engineering or related discipline with aptamer biosensors focus.
• Post doctoral experience is a plus.

Responsibilities

• Design, prototype, and optimize electrochemical biosensor systems for small molecule analytes.
• Apply surface chemistry and electrode modification to improve sensitivity and selectivity.
• Translate bio-element interactions into measurable sensor outputs through novel assay design.
• Use electrochemical methods (voltammetry, impedimetry, chronoamperometry) to characterize biosensor function.
• Utilize Python-based analysis and DoE to streamline workflows.
• Troubleshoot technical and conceptual challenges and propose improvements.
• Develop and maintain SOPs ensuring reproducibility and compliance with quality standards.
• Collaborate with chemists, biologists, engineers, and data scientists to advance prototypes.

Skills

Biosensor design

Electrochemical techniques

Aptamers

Small molecule detection

Biofluids analysis

Python

DoE (Design of Experiments)

Troubleshooting

Multidisciplinary teamwork

Education

PhD in Electrochemistry/Analytical Chemistry/Biochemistry or related

Tools

SPR (Nice to have)

Python scripting

Job description

About Level Zero

Level Zero is pioneering next-generation biosensor technology for precise, real-time monitoring of critical endocrine biomarkers. Recognised as one of the top 20 startups across all categories worldwide at TechCrunch Disrupt 2024-and backed by top-tier organisations like SOSV and Entrepreneur First,we're pushing the boundaries of biochemistry and nanotechnology to revolutionise personalised health.

Founded by two seasoned engineers, we bring extensive experience in R&D, technical innovation, and commercial strategy to transform the way people monitor their health. Our mission is bold: to revolutionise health management by delivering clinical-grade data directly to individuals, wherever they are.

We're seeking driven innovators to join us in pushing the boundaries of biosensing and health tech, making personalised health monitoring a reality for everyone. To achieve this ambitious vision, we're assembling the best team in the world-dedicated to turning cutting-edge science into life-changing, real-world solutions.

About The Role

We are excited to welcome a biosensor scientist with a strong background in electrochemical biosensor R&D and experience in working with aptamers to join our rapidly growing start-up. The ideal candidate is expected to be proficient in bench and wet chemistry techniques. Moreover, they should have sound knowledge and experience in assay development, small molecule detection, and electrode surface modifications. It is essential for the candidate to have extensive experience in aptamer-based electrochemical biosensor R&D, including the designs, operation principles, troubleshooting, and analysis.

This is a full-time, in-person role primarily based in London.

Some examples of what you might do:

• Design, prototype, and optimize electrochemical biosensor systems, focusing on small molecule analytes and aptamer-based recognition
• Apply surface chemistry and electrode modification strategies to improve sensitivity, selectivity, stability, and biosensor performance in complex biological samples
• Translate bio-element-target interactions into measurable and reproducible sensor outputs through novel assay design
• Apply a range of electrochemical methods (voltammetry, impedimetry, chronoamperometry, etc.) to characterize and evaluate biosensor function
• Apply data-driven approaches including Python-based analysis and Design of Experiments (DoE) to streamline workflows
• Troubleshoot technical and conceptual challenges systematically and propose innovative solutions to improve performance
• Develop and maintain Standard Operating Procedures (SOPs) and ensure experimental reproducibility and compliance with quality standards
• Collaborate effectively with cross-functional teams (chemists, biologists, engineers, and data scientists) to advance biosensor prototypes from concept to application
• Present results clearly through written reports, oral presentations, and scientific publications
• Attend R&D-related trainings and seminars for continuous updates on the latest trend in hormone sensing technologies

What You Bring

• A Ph. D. degree in Electrochemistry, Analytical Chemistry, Biochemistry, Chemical/Materials Engineering or related discipline, with a focus in aptamer biosensors. Post doctoral experience will be a plus for this role

The ideal candidate will possess expertise in the following areas:

• Proven hands-on experience in biosensor design, electrochemical techniques, and surface chemistry optimisation
• Proficiency in operating electrochemical instrumentation and analyzing experimental data
• Demonstrated expertise with biorecognition elements, particularly aptamers, for biosensor applications
• Strong knowledge of small molecule detection in biological and/or environmental samples
• Practical experience in handling and analyzing biofluids
• Excellent problem-solving and troubleshooting skills
• Creative and open mindset with the ability to explore and implement novel approaches
• Strong interpersonal and communication skills, with experience working in multidisciplinary teams

Nice to have:

• Experience with Surface Plasmon Resonance (SPR), molecular docking, or structural modeling
• Familiarity with automation, Python scripting, and statistical design approaches (DoE)
• Track record of peer-reviewed publications, patents, or industry-led biosensor projects

Who You Are

• We value culture as much as we value technical expertise, creating an environment that's equal parts collaboration, curiosity, and fun

We're a fast-paced, mission-driven young team on a quest to make a lasting impact, fueled by uncompromising integrity, unwavering support for one another, and the thrill of exploring uncharted territories. Our passion for excellence drives everything we do, and we welcome individuals who share our commitment to shaping the future.

If our vision excites you, here are the qualities we look for:

• You live and breathe integrity, tackling challenges with honesty and transparency
• You're a self-starter who loves diving into the unknown, collaborating on complex problems, and taking full ownership of results
• You excel at open, clear communication and see every piece of feedback as a springboard for growth - especially in a science and data-focused environment
• You're motivated by creating real impact, particularly when it comes to advancing human health
• You strike a balance between independence and collaboration, knowing when to seek support or invite others to join in
• You're confident in defending your ideas, while also valuing respectful, constructive debate as a path to better solutions
• You thrive in the dynamic atmosphere of a startup, constantly evolving your skill set and fearlessly applying what you learn

What We Offer

• A full-time role with a competitive salary and equity options, reflecting our value in your expertise and potential
• An environment where you'll collaborate directly with the founding team at a leading biosensor startup, gaining access to industry experts and thought leaders
• The chance to grow with us, including ample opportunities for leadership, career advancement, and exploration
• Travel to New York and other potential sites for R&D purposes
• The excitement of working on cutting-edge technology, shaping strategic decisions, and driving innovation at an early-stage venture alongside a superstar team