Biophysics Technician (SPR/GCI)

Level Zero Health; Greater London; On-site; GBP 35,000 - 55,000; Full time

Benefits offered by this job

Equity options

Travel to New York

Career growth opportunities

Job summary

Level Zero Health is seeking a hands‑on technician to run label‑free biophysical instruments (SPR, GCI, ITC or BLI) to characterize receptor–hormone binding and ligand kinetics. You’ll troubleshoot, prepare samples, and contribute to real‑time biosensor development.

You’ll work closely with scientists, tackle data artefacts, and help refine methods for challenging targets, with travel to NY and other R&D sites as part of an exciting early‑stage venture.

Qualifications

• 1‑2 years of hands‑on experience running biophysical characterisation instruments (SPR, GCI, ITC or BLI)
• Experience with protein or small‑molecule binding studies and basic kinetic analysis
• Awareness of common pitfalls in small‑molecule binding, such as mass transport effects and solvent correction
• Strong attention to detail, careful record‑keeping and a methodical approach to troubleshooting
• Bonus: experience with aptamers or other nucleic acid‑small molecule interactions, hydrophobic targets, complex sample matrices, or ITC

Responsibilities

• Run binding experiments on receptor‑hormone interactions using GCI, SPR and ITC, following established methods
• Prepare samples, buffers and sensor chips, and maintain instruments to keep data quality consistent
• Measure binding kinetics (on‑rates and off‑rates) and affinity, and spot and flag common data artefacts
• Troubleshoot routine issues such as non‑specific binding and carry‑over, working with the team to optimise buffers, additives and cleaning protocols
• Support method refinement for difficult, poorly soluble targets
• Run assays in realistic biological samples to help assess how other components affect results
• Document methods and results clearly, and share findings with the wider team

Skills

Biophysical instruments

Binding kinetics

Data quality control

Troubleshooting

Attention to detail

Tools

SPR

GCI

ITC

BLI

Job description

About Level Zero

Level Zero is pioneering next-generation biosensor technology for precise, real-time monitoring of critical endocrine biomarkers. Recognised as one of the top 20 startups across all categories worldwide at TechCrunch Disrupt 2024 - and backed by top-tier organisations like SOSV and Entrepreneur First - we're pushing the boundaries of biochemistry and nanotechnology to revolutionize personalised health.

Founded by two seasoned engineers, we bring extensive experience in R&D, technical innovation, and commercial strategy to transform the way people monitor their health. Our mission is bold: to revolutionise health management by delivering clinical-grade data directly to individuals, wherever they are.

We're seeking driven innovators to join us in pushing the boundaries of biosensing and health tech, making personalised health monitoring a reality for everyone. To achieve this ambitious vision, we're assembling the best team in the world - dedicated to turning cutting‑edge science into life‑changing, real‑world solutions.

About The Role

We’re looking for a technician with hands‑on experience running label‑free biophysical instruments (SPR, GCI, BLI or ITC) to assist with characterising how receptors bind to hormone targets. You’ll focus on ligand kinetics screening, and your results will directly help us select and refine the receptors that go into our real‑time, continuous biosensors.

Our targets are challenging small molecules that are hard to handle and tend to stick to surfaces, so careful experimental technique and attention to detail are central to the role. You’ll run established screening methods, troubleshoot day‑to‑day issues, and work closely with our scientists as methods continue to improve.

What You’ll Do

• Run binding experiments on receptor‑hormone interactions using GCI, SPR and ITC, following established methods
• Prepare samples, buffers and sensor chips, and maintain instruments to keep data quality consistent
• Measure binding kinetics (on‑rates and off‑rates) and affinity, and spot and flag common data artefacts
• Troubleshoot routine issues such as non‑specific binding and carry‑over, working with the team to optimise buffers, additives and cleaning protocols
• Support method refinement for difficult, poorly soluble targets
• Run assays in realistic biological samples to help assess how other components affect results
• Document methods and results clearly, and share findings with the wider team

What You Bring

• 1‑2 years of hands‑on experience running biophysical characterisation instruments (SPR, GCI, ITC or BLI)
• Experience with protein or small‑molecule binding studies and basic kinetic analysis
• Awareness of common pitfalls in small‑molecule binding, such as mass transport effects and solvent correction
• Strong attention to detail, careful record‑keeping and a methodical approach to troubleshooting
• Bonus: experience with aptamers or other nucleic acid‑small molecule interactions, hydrophobic targets, complex sample matrices, or ITC

Who You Are

We value culture as much as we value technical expertise, creating an environment that's equal parts collaboration, curiosity, and fun.

We're a fast‑paced, mission‑driven young team on a quest to make a lasting impact, fueled by uncompromising integrity, unwavering support for one another, and the thrill of exploring uncharted territories. Our passion for excellence drives everything we do, and we welcome individuals who share our commitment to shaping the future.

If our vision excites you, here are the qualities we look for:

• You live and breathe integrity, tackling challenges with honesty and transparency
• You're a self‑starter who loves diving into the unknown, collaborating on complex problems, and taking full ownership of results
• You excel at open, clear communication and see every piece of feedback as a springboard for growth—especially in a science and data‑focused environment
• You're motivated by creating real impact, particularly when it comes to advancing human health
• You strike a balance between independence and collaboration, knowing when to seek support or invite others to join in
• You're confident in defending your ideas, while also valuing respectful, constructive debate as a path to better solutions
• You thrive in the dynamic atmosphere of a startup, constantly evolving your skill set and fearlessly applying what you learn

What We Offer

• A full‑time role with a competitive salary and equity options, reflecting our value in your expertise and potential
• An environment where you'll collaborate directly with the founding team at a leading biosensor startup, gaining access to industry experts and thought leaders
• The chance to grow with us, including ample opportunities for leadership, career advancement, and exploration
• Travel to New York and other potential sites for R&D purposes
• The excitement of working on cutting‑edge technology, shaping strategic decisions, and driving innovation at an early‑stage venture alongside a superstar team