Bionow - Postdoctoral Scientists - Systems Oncology Group

Bionow; Manchester; On-site; GBP 37,000 - 45,000; Full time

Job summary

Bionow is seeking a Postdoctoral Scientist to join the Systems Oncology Group at the Cancer Research UK Manchester Institute. This role involves contributing to groundbreaking research on tumor microenvironments and therapeutic responses, requiring a PhD in a related field and expertise in various molecular biology techniques. The dynamic laboratory environment offers the chance to engage in impactful cancer research while collaborating with a multidisciplinary team.

Qualifications

• Experience in protein biochemistry and cell signalling analysis.
• Experience in cancer in vitro models is essential.
• Experience with in vivo tumour models is desirable.

Responsibilities

• Conduct in vitro cell biology assays and biochemical assays for cell signalling.
• Perform functional CRISPR screening and mass spectrometry analysis.
• Analyze tumor models via immunofluorescence, immunohistochemistry, proteomics, genomics.

Skills

Independent thinking

Teamwork

Strong communication

Education

PhD in biochemistry, cancer biology, cell biology, immunology

Job description

Bionow - Postdoctoral Scientists - Systems Oncology Group

Job Title: Postdoctoral Scientists - Systems Oncology Group
Category: Technical roles
Closing Date: 06/07/2025

Salary starting: £37,000 - £44,852 (depending on qualifications and experience)
Duration: Fixed term until 28 February 2027

About the role:

Dr Claus Jorgensen, Group Leader of the Systems Oncology Group, is seeking a Postdoctoral Scientist to join his team. This role offers an exciting opportunity for a motivated, innovative, and organized individual to contribute to cutting-edge research in a dynamic laboratory.

The Systems Oncology Group aims to understand how the tumour microenvironment and desmoplastic reaction influence tumour cell function and therapeutic response in pancreatic ductal adenocarcinoma. We have identified a novel target involved in tumour-microenvironment interactions, which may serve as a future therapeutic target.

The successful candidate will characterise this target's role in regulating tumour and host cells and their interactions. Responsibilities include conducting in vitro cell biology assays, biochemical assays for cell signalling, functional CRISPR screening, and mass spectrometry analysis in 2D and 3D models. Tumour models will be analyzed via immunofluorescence, immunohistochemistry, proteomics, genomics, and transcriptional profiling, alongside testing combination treatments using in vivo models (see Hutton et al Cancer Cell 2021, Lee et al Nat Comm 2021, Below et al Nat Mat 2022). This project is ideal for a collaborative individual eager to make an impact in a challenging cancer type.

About you:

You should hold a PhD in biochemistry, cancer biology, cell biology, immunology, or a related discipline. Experience in protein biochemistry, cell signalling analysis, and cancer in vitro models is essential. Experience with in vivo tumour models and immunology is desirable. Key qualities include independent thinking, teamwork, and strong communication skills, vital for working effectively in a multidisciplinary environment.

Why choose Cancer Research UK Manchester Institute?

The Cancer Research UK Manchester Institute, part of The University of Manchester, is a leading cancer research centre. It is funded by Cancer Research UK, the world's largest independent cancer research organization. In 2023, the Institute moved to the state-of-the-art Paterson Building, a £150 million biomedical research centre attached to The Christie NHS Foundation Trust in South Manchester. Partnering with The Christie NHS Foundation Trust, one of Europe's largest cancer treatment centres, offers an exceptional environment for basic, translational, and clinical research.

How to apply?

Visit our website: https://www.cruk.manchester.ac.uk/careers/

For informal enquiries, contact Dr Claus Jorgensen via email: [e-mail]

Closing date: Sunday, 6 July 2025

First round interviews: w.c. 21 July 2025