Bioinformatician

ONE NUCLEUS; Cambridge; On-site; GBP 35,000 - 50,000; Full time

Job summary

ONE NUCLEUS is seeking a proactive bioinformatician to lead the management of bioinformatics pipelines in a rapidly growing biotechnology startup. This role offers the opportunity to work at the intersection of biology and technology, contributing directly to innovative research and cutting-edge projects in genomics.

Benefits

Employee share option plan

Private health insurance

Pension plan (matching up to 8%)

On-site parking

Collaborative environment

Qualifications

• Previous experience as a bioinformatician in an industrial setting preferred.
• Strong understanding of bioinformatics workflows.
• Familiarity with database design is advantageous.

Responsibilities

• Take ownership of bioinformatics pipelines and improve workflows.
• Perform quality control of sequencing data.
• Collaborate closely with laboratory scientists.

Skills

Nextflow

Python

Molecular Biology

Genomics

Problem-solving

Communication

Education

MSc in Bioinformatics, Computational Biology, or a related field

Tools

Docker

Singularity

Terraform

Ansible

Job description

Constructive Bio is a VC-backed biotechnology start-up based in Whittlesford, Cambridge. Our breakthrough technology harnesses the power of genome rewriting and genetic code reprogramming to make valuable products that positively impact the world. We will use our platform to turn cells into bio-renewable factories to produce novel molecules that were previously inaccessible to natural biology, with diverse applications in industries spanning healthcare, biological research, materials and electronics.

We are seeking a proactive bioinformatician to join ourbioinformatics team. You will take ownership of our bioinformatics pipelines, ensuring they are reliable, efficient, and aligned with the evolving needs of high-throughput research. You’ll
collaborate closely with laboratory scientists, within a supportive team of bioinformaticians,on a diverse range of impactful projects, contributing directly to cutting-edge research in biotechnology.

Responsibilities:

• Take ownership of running and monitoring our bioinformatics pipelines, helping ensure data flows efficiently from raw sequencing to downstream analysis.
• Identify opportunities to automate and enhance existing bioinformatics workflows to improve efficiency and reliability.
• Adapt workflows when needed to better meet the needs of experimental scientists and project-specific requirements.
• Perform basic quality control, formatting, and organization of sequencing and metadata to ensure smooth downstream analysis.
• Be a champion of best practises for bioinformatics software (such as containerisation, version control, pipeline management).
• Proactively stay in regular contact with scientists and other teams to plan ahead for sequencing runs and make sure data is delivered on time.
• MSc in Bioinformatics, Computational Biology, or a related field. Candidates with experience working as a bioinformatician in an industrial setting will be preferred.
• Previous experience with Nextflow, cloud-based pipeline development and object-oriented programming (Python).
• Strong understanding of molecular biology and genomics.
• Strong problem-solving skills and the ability to work independently in a fast-paced environment.
• Excellent written and oral communication skills and ability to work collaboratively in a team.
• Familiarity
  with developing and deploying containerized workflows using Docker or Singularity to ensure reproducibility.
• Familiarity with infrastructure automation tools (such as Terraform and Ansible) would be an advantage.
• Experience of working with and designing databases would be an advantage.
  

What’s in it for you? Why work at Constructive Bio?

We are a small but rapidly growing team, with a vision to become the programmable biomolecules company and push the boundaries of what’spossible between biology and chemistry. As an early joiner, you will have a unique opportunity to help shape our trajectory and make real impact from day one.

We offer:

• Newly fitted dedicated site in Whittlesford near Cambridge – on-site parking and regular trains to Cambridge, London and Norwich
  
• Employee share option plan
  
• Private health insurance
  
• Pension plan (matching up to 8%)
  
• Collaborative and pioneering environment, at the leading edge of synthetic genomics and engineered translation
  

We want to build a team with trust and respect for each other and create a culture of collaboration, openness, curiosity, and scientific excellence.

We are built on three principles:

• We imagine:We think big and plan our own path for success.
  
• We pioneer:We take action and grow together as one to break moulds.
  
• We deliver:We take ownership and work together to deliver excellence.
  

Constructive Bio is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.