AZ Funded Non Clinical PhD Studentship (Fixed Term) - A reproducible human lung organoid platfo[...]

TN United Kingdom; Cambridge; On-site; GBP 22,000; Full time

Job summary

An established industry player is offering an exciting opportunity for a PhD studentship focused on developing a human lung organoid platform for large-scale oncology CRISPR screens. This innovative project, based at the University of Cambridge, combines cutting-edge research in cell biology and cancer studies. The successful candidate will work under esteemed supervision, gaining invaluable experience in a collaborative environment. With full funding and access to extensive training and mentorship, this role is perfect for a motivated individual ready to make a significant impact in the field of oncology research. Apply now to embark on this rewarding academic journey!

Qualifications

• Motivated individual capable of independent work.
• Background in cell or developmental biology or biochemistry.

Responsibilities

• Work on a collaborative project at the University of Cambridge.
• Develop human lung organoid models for oncology research.

Skills

Cell Biology

Developmental Biology

Biochemistry

Research Skills

Education

First or upper second-class degree

Job description

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AZ Funded Non Clinical PhD Studentship (Fixed Term) - A reproducible human lung organoid platform for large scale oncology CRISPR screens, Cambridge

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Client:

University of Cambridge

Location:

Cambridge, United Kingdom

Job Category:

Other

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EU work permit required:

Yes

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Job Reference:

43cf3e49dfbe

Job Views:

1

Posted:

07.05.2025

Expiry Date:

21.06.2025

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Job Description:

Applications are invited for a 4-year PhD studentship based in the Department of Physiology, Development and Neuroscience (PDN)/Gurdon Institute, University of Cambridge, and the new AstraZeneca Discovery Centre at Cambridge. The student will work on a collaborative project jointly supervised by Prof Rawlins in PDN/Gurdon and Dr Luigi Aloia at AstraZeneca, with opportunities to work across both sites.

The project, titled 'A reproducible human lung organoid platform for large scale oncology CRISPR screens,' focuses on human organoid/cancer biology, a rapidly advancing field of interest in academia and industry.

Project abstract: Lung cancer exhibits heterogeneity. Variability between patients, tumors, and within tumors affects drug efficacy and resistance. To identify and validate oncology drug targets, we need human-relevant models that capture patient heterogeneity. Human lung organoids are promising for modeling the tumor microenvironment, but their growth can be unreliable. We hypothesize that effects of cancer driver mutations are conserved across different genetic backgrounds, representing real-life heterogeneity, which we will test using genetic engineering to develop human lung adenocarcinoma models from multiple donors. This will enable the development of scalable cellular models to study lung cancer development and progression.

Candidate

We seek a motivated individual capable of independent work, with a background in cell or developmental biology or biochemistry. Applicants should have or expect to obtain a first or upper second-class degree from a UK university or an equivalent from an overseas university. The position is open to UK citizens and eligible overseas students who can cover additional international fees through scholarships or funding schemes. Self-funding is not permitted.

Further details on entrance requirements and scholarships are available on the university website.

Funding

The studentship provides full funding, including maintenance fees at £21,500 per annum and the university's composition fee, starting from 1 October 2025.

Application Process

• Full-time PhD in Physiology, Development & Neuroscience
• Start Date: 1st October 2025
• Project Title: AZ funded non-clinical PhD Studentship in 'Human lung organoid platform for oncology'
• Research Proposal: Include the project abstract above

Applications should include:

• Two academic references
• Transcript
• CV/resume
• Evidence of English competence (if required)
• Statement of Interest
• Widening Participation Questionnaire

Deadline

Apply via the portal by 23:59 UK time on 11th November 2024. Interviews will be held at the end of November.

As a Cambridge graduate student, you'll have access to extensive training and supervision, including interactions with AZ mentors and periods working at AZ. The program encourages attendance at various seminars, training courses, and symposia to support your development.

Diversity and Inclusion

The university promotes equality, diversity, and inclusion, fostering a supportive environment for cutting-edge research. Eligibility to work in the UK is required for all employees.