Associate Scientist II

BioPharma Consulting JAD Group; Cambridge; On-site; GBP 80,000 - 100,000; Full time

Job summary

A biopharmaceutical consulting firm in Cambridge is seeking an experienced Research Associate Scientist II. The role involves conducting cell culture, performing RNASeq sample preparation, and enhancing laboratory protocols. Candidates must have a BS in biological science and at least 2 years of laboratory experience in a collaborative setting. This position offers the potential for contract extension.

Qualifications

• Minimum 2 years of hands-on laboratory experience in cell or molecular biology.
• Experience in cell culture and purification/quantification of nucleic acids/protein.
• Excellent interpersonal skills for a collaborative environment.

Responsibilities

• Perform cell culture to support research needs.
• Execute RNASeq sample preparation and maintain records.
• Conduct assays for quantitative analysis of biomarkers.

Skills

Cell culture

Molecular biology

Analytical skills

NGS workflow

Education

BS in biological science

Tools

Liquid handling systems

qPCR

Job description

The experienced Research Associate Scientist II, with a background in in vitro screening, will be part of our dynamic, fast-paced and interdisciplinary lead development team. Our mission is to advance novel RNAi therapeutic programs from target discovery through lead candidate selection. The Associate Scientist II will be technically skilled in molecular and/ or cell biology, and bring a rigorous, analytical approach to research.

Key Responsibilities

• Perform cell culture (iPSCs, primary cells, immortalized cell lines) to support the research needs of the group and high-throughput screening of siRNAs using qPCR and a variety of cell-based assays
• Execute day to day operations for RNASeq sample preparation, including: library preparation, QC and sequencing. Maintain sample tracking & records.
• Conduct assays that support in vivo studies (e.g. qPCR, ELISA) for the quantitative analysis of biomarkers or siRNA activity
• Support lab maintenance including equipment operation & maintenance , reagent inventory and reagent preparation
• Troubleshoot technical problems and participate in the continuing development and optimization of existing and new protocols.
• Utilize instrumentation and robotics to aid in high throughput (384-well) screening.
• Adapts well to the changing platform needs, in workflow, projects and other tasks as required by the platform.

Qualifications

• BS in a biological science with at least 2 years of hands-on laboratory experience in cell or molecular biology are required
• Experience in cell culture and purification/quantification of nucleic acids/protein, including qPCR
• Experience with NGS workflow is desired
• Experienced with laboratory automation including liquid handling systems such as Perkin Elmer JANUS, Beckman i7 or other systems.
• Excellent interpersonal skills with the ability to work well with others in a dynamic and highly collaborative environment.

• Contract with possible extension