Associate Scientist, Exploratory Diagnostics - Translational Medicine

Immunocore; Oxford; On-site; GBP 30,000 - 50,000; Full time

Job summary

Join a pioneering biotechnology company as an Associate Scientist in Exploratory Diagnostics, where you'll leverage your expertise in immunohistochemistry and immunofluorescence to conduct critical experiments on clinical samples. This role offers the chance to work in a dynamic environment focused on developing transformative therapies for unmet patient needs. Collaborate with a talented team dedicated to innovation and excellence in translational medicine. If you're passionate about advancing science and making a difference in patients' lives, this is the opportunity for you. Embrace a culture that values diversity, integrity, and collaboration while contributing to groundbreaking research in oncology and autoimmune diseases.

Qualifications

• Strong background in immunology and cancer biology is essential.
• Experience with IHC and IF assays on human samples required.
• Proficient in data recording and Microsoft Office tools.

Responsibilities

• Conduct experimental investigations using IHC and IF techniques.
• Ensure compliance with health and safety requirements.
• Maintain accurate laboratory records and data.

Skills

Immunohistochemistry (IHC)

Immunofluorescence (IF)

Tissue sectioning

Histology

Data recording

Microsoft Office

Education

BSc in Biological Sciences

MSc in Oncology or Immunology

Tools

Microtome

Cryostat

Laboratory equipment

Job description

Job Details: Associate Scientist, Exploratory Diagnostics - Translational Medicine

Vacancy Name: Associate Scientist, Exploratory Diagnostics - Translational Medicine

Vacancy No: VN511

Employment Type: Permanent

Location of role: Oxford, UK

Department: Translational Medicine

Key Responsibilities

The Associate Scientist will conduct experimental investigations using IHC or IF to analyse clinical trial and non-clinical tissue samples, with supervision and guidance from colleagues and managers, enabling the advancement of the Company pipeline, process, or technology capabilities.

1. Experiments: running pre-established experimental investigations, with guidance from line managers, a mentor or colleagues.
2. Priorities: working to agreed experimental priorities and deadlines; raising issues or concerns with managers or colleagues so that these can be addressed.
3. Technical knowledge: actively developing own knowledge, drawing on the experience of others and self-learning.
4. Laboratory records: Ensuring that all records and data are up to date, on time and recorded to the correct standard, checking with a mentor or colleagues if unsure.
5. Laboratory equipment: attending training on the use of technical instruments, using equipment appropriately, correctly and tidily.
6. Health & Safety: compliance with all H&S requirements, attending appropriate training programmes.

Specific Responsibilities

1. Performing Immunohistochemical analysis on patient samples from clinical trials using previously established assays.
2. Performing Singleplex or Multiplex Immunofluorescence assays on patient samples from clinical trials, following previously established protocols.
3. Performing experimental procedures, equipment maintenance and keeping experimental and maintenance records in accordance with HTA/GCP standards as relevant.

Experience and Knowledge

Essential

1. Background in immunology and/or cancer biology.
2. Experience in the following techniques:

• Tissue sectioning with microtome and/or cryostat.
• Histology (H&E staining and/or other special stains).
• Immunohistochemistry (manual and/or autostainers).

Worked as an experimental scientist with expertise in relevant immunohistochemistry (IHC) and immunofluorescence (IF) assays to analyse human samples.

Recorded results and information in a concise, accurate and timely way as part of studies or in a work environment.

Learnt about new practices based through observation, self-learning and an enquiring mind.

Basic competence in Microsoft office package such as Outlook, Excel, PowerPoint.

Desirable

1. Worked in a diverse team environment.
2. Experience with immuno-pathology.
3. Experience analysing clinical trial samples with IHC or IF based biomarkers.
4. Experience working with patient samples from clinical trials.
5. Experience in a GCP-regulated environment, following SOPs and Analytical Plans.
6. Experience with HTA regulation.
7. Experience in some of the following techniques:

• FFPE and frozen sample preparation.
• Use of microscope and Digital image acquisition.
• Digital image analysis.
• RNA in situ hybridization, multiplex IHC/IF.

Key Behavioural Attributes

1. Openness and honesty: Readily offering information pertaining to work in hand whether positive or negative.
2. Taking responsibility: Being prepared to accept full responsibility for tasks entrusted to them; seeing tasks through to completion and dealing with the consequences of failure or success.
3. Flexibility: Being flexible to new ideas and approaches; changes of plans, objectives and/or priorities. Handling disjointed tasks effectively.
4. Team spirit: Being able to work productively with others to achieve tasks. Showing consideration for the needs and feelings of others.

Specific Behavioural Attributes

1. Analytical Thinking: Tackling problems using a logical, systematic and sequential approach, identifying discrepancies and inconsistencies.
2. Attention to Communication: Ensuring information is passed as required, keeping managers informed on progress and problems, avoiding surprises.
3. Diagnostic Information Gathering: Identifying the information required to clarify a situation, asking questions when required.
4. Managing Self Performance: Taking responsibility for own performance, clarifying expectations and promptly notifying managers/colleagues of problems affecting potential completion of goals.
5. Results Orientated: Focusing on desired results, overcoming obstacles and sometimes frustration, with an urgency to get things done.
6. Teamwork: Working cooperatively as part of a team, actively listening and constructively responding to others ideas.
7. Thoroughness: Ensuring work and information provided is complete, carefully reviewing and checking the accuracy of information and work.
8. Written and oral communication: Writing and speaking clearly to share thoughts and information concisely and appropriately.

Education & Qualifications

BSc. Or MSc. in Biological Sciences, Oncology, Immunology or other related discipline

About the Company

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.

At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients’ lives, advancing medicine, and supporting one another in these pursuits.

Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.