Associate in RNA-based Therapeutics for Cardiovascular Disease Post-doctoral Research

KINGS COLLEGE LONDON; United Kingdom; On-site; GBP 46,000; Full time

Job summary

A leading university in the UK is seeking a motivated Postdoctoral Research Associate to join a dynamic research team focusing on cardiovascular and metabolic research. Successful candidates will have a PhD in a biological sciences discipline and expertise in cellular models relevant to cardiovascular disease. This full-time position offers a fixed term contract until August 2027 with a competitive salary and opportunities for professional development.

Benefits

Entitlement to 10 days per year for professional development

Qualifications

• Proven experience in culturing neonatal rat ventricular myocytes or iPSC-derived cardiomyocytes.
• Strong skills in protein analysis, molecular biology, and imaging techniques.
• Additional expertise in studying autophagy and using preclinical mouse models of cardiovascular disease are highly desirable.

Responsibilities

• Investigate microRNAs identified through a high-content screening approach.
• Evaluate the potential of microRNAs as therapeutic targets in cardiovascular disease.

Skills

PhD in cardiovascular Biochemistry/Physiology

Strong background in biochemistry and molecular biology

Tissue/cell culture experience

Culturing neonatal rat ventricular myocytes

Broad cell biology experience

Expertise with studying autophagy

Expertise in preclinical mouse models

Education

PhD in biological sciences discipline

Job description

Organisation/Company KINGS COLLEGE LONDON Research Field Biological sciences Chemistry Researcher Profile Recognised Researcher (R2) Established Researcher (R3) Country United Kingdom Application Deadline 14 Aug 2025 - 00:00 (UTC) Type of Contract Other Job Status Full-time Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

About Us

The School of Cardiovascular and Metabolic Medicine & Sciences (SCMMS) provides an outstanding multi-disciplinary environment for the pursuit of cutting-edge cardiovascular and metabolic research. We study the fundamental molecular, cellular, and physiological processes that underly normal and abnormal cardiovascular and metabolic function and drive the translation of this strong basic science into advances in clinical practice. Our research focuses on four main Themes (Cardiac, Vascular, Cardiometabolic, Diabetes & Obesity), with two cross-cutting Themes (Basic and Clinical). The School is led by Professor Mauro Giacca and comprises over 65 clinical and non-clinical academic groups, hosting 400 personnel and 110 PhD students. Our community of world-renowned researchers and educators have access to state-of-the art core facilities and expertise, including facilities for high-throughput screening and high content imaging, multimodality in vivo imaging, proteomics, integrative physiology and viral & non-viral vector production. The School activities are carried out at three main locations: James Black Centre in Denmark Hill, St Thomas’s Hospital and Franklin-Wilkins Building in South Bank and the Hodgkin Building and New Hunt House/Randal Centre in Guy’s Campus. As part of King’s Health Partners, we have an excellent environment for basic-clinical interaction and a strong focus on mentoring and career development. The School hosts the British Heart Foundation Centre of Research Excellence at King's, which brings together a unique range of internationally recognised scientists and clinicians from across the School and King’s College London.

Applications are invited for a highly motivated Postdoctoral Research Associate with expertise in studying signalling pathways in neonatal rat ventricular myocytes or iPSC-derived cardiomyocytes. The position is based in Dr Joseph Burgoyne’s group at the Rayne Institute, St Thomas’ Hospital, part of King’s College London.

The successful candidate will investigate microRNAs identified through a high-content screening approach, aiming to evaluate their potential as therapeutic targets in cardiovascular disease.

Applicants must hold a PhD in a biological sciences discipline and have proven experience in culturing neonatal rat ventricular myocytes or iPSC-derived cardiomyocytes, alongside strong skills in protein analysis, molecular biology, and imaging techniques. Additional expertise in studying autophagy and using preclinical mouse models of cardiovascular disease are highly desirable.

This is a full time post (35 hours per week), and you will be offered a fixed term contract until 9th August 2027.

Research staff at King’s are entitled to at least 10 days per year (pro-rata) for professional development. This entitlement, from the Concordat to Support the Career Development of Researchers, applies to Postdocs, Research Assistants, Research and Teaching Technicians, Teaching Fellows and AEP equivalent up to and including grade 7. Visit the Centre for Research Staff Development for more information.

About You

To be successful in this role, we are looking for candidates to have the following skills and experience:

• PhD in cardiovascular Biochemistry/Physiology
• Strong background in biochemistry and molecular biology
• Tissue/cell culture experience
• Culturing neonatal rat ventricular myocytes or generating iPSC-derived cardiomyocytes
• Broad cell biology experience, e.g. immunoblotting, primary cell culture, confocal microscopy, immunofluorescence
• Motivated and hard-working.
• Ability to integrate with colleagues, work as part of a team and undertake share of group tasks.
• Able to carry out know/learnt techniques unsupervised, and flexible/able to change in current professional context.
• Able to plan and prioritise workload and keep clear and well-organised laboratory notes and records.
• Background in cardiovascular biology
• Expertise with studying autophagy
• Expertise in preclinical mouse models of cardiovascular disease

Downloading a copy of our Job Description

Full details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the page. This document will provide information of what criteria will be assessed at each stage of the recruitment process.

Further Information

We pride ourselves on being inclusive and welcoming. We embrace diversity and want everyone to feel that they belong and are connected to others in our community.

We are committed to working with our staff and unions on these and other issues, to continue to support our people and to develop a diverse and inclusive culture at King's.

As part of this commitment to equality, diversity and inclusion and through this appointment process, it is our aim to develop candidate pools that include applicants from all backgrounds and communities.

We ask all candidates to submit a copy of their CV, and a supporting statement, detailing how they meet the essential criteria listed in the advert. If we receive a strong field of candidates, we may use the desirable criteria to choose our final shortlist, so please include your evidence against these where possible.

To find out how our managers will review your application, please take a look at our‘How we Recruit ’ pages.

Interviews are due to be held on the 26 - 29th August.

Grade and Salary:£45,497 per annum inclusive of London Weighting Allowance

Job ID:121705

Close Date:14-Aug-2025

Contact Person:Joseph Burgoyne

Contact Details:[e-mail]