Antibody Discovery and Engineering Scientist

Next-Link; Slough; On-site; GBP 40,000 - 70,000; Full time

Job summary

Next-Link, a leader in antibody drug discovery, is seeking an Antibody Discovery Scientist to join their innovative team. This laboratory-based position demands expertise in molecular biology and protein biochemistry, focusing on developing monoclonal antibodies and utilizing cutting-edge methodologies in antibody design and engineering. Ideal candidates will be PhD qualified with experience in display libraries and possess strong analytical skills.

Qualifications

• PhD or equivalent in molecular biology and protein biochemistry, ideally in antibody discovery.
• Experience with in vitro display libraries and biochemical techniques.
• Skills in computational platforms for data analysis are advantageous.

Responsibilities

• Contribute to therapeutic monoclonal antibody discovery.
• Utilise yeast display techniques and design synthetic display libraries.
• Prepare NGS libraries and analyse data for antibody engineering.

Skills

Attention to detail

Data analysis

Communication

Education

PhD in molecular biology

Tools

Flow cytometry

Surface plasmon resonance

Bio-layer interferometry

Job description

Job Description

Role overview

Our client is a world leader in antibody drug discovery and development. This is a unique opportunity to join the Antibody Discovery team working with cutting-edge technologies to help shape the delivery of next-generation antibody therapeutics.

This role offers the chance to be part of a dynamic team of scientists developing and validating new sequence-based and structure-based antibody design approaches, including hit identification, sequence optimisation, and in silico de novo antibody design. It is a laboratory-based position requiring detailed knowledge of molecular biology and microbiological methods, with a proven track record in antibody discovery or protein engineering as a significant advantage.

Responsibilities

• Contribute to the discovery of therapeutic monoclonal antibodies to support the pipeline and benefit patients with serious diseases.
• Utilise cutting-edge yeast display techniques for discovering and optimising human antibodies aligned with therapeutic targets.
• Design, construct, and perform selections using bespoke synthetic display libraries to support in silico de novo antibody discovery and optimisation projects.
• Prepare next-generation sequencing (NGS) libraries and analyse data to support antibody discovery and engineering of lead molecules.
• Collaborate with computational and CADD scientists to develop and apply AI/Deep learning solutions and structure-based approaches for high-quality antibody engineering.
• Develop and implement new methodologies in antibody display and engineering.
• Work across project teams to ensure timely delivery of results.
• Present experimental data at cross-functional meetings.

Requirements

• PhD or equivalent in molecular biology and protein biochemistry, ideally within the antibody space.
• Experience with in vitro display libraries for discovery, affinity maturation, or other protein engineering, preferably with structure or deep sequence-guided insight.
• Experience with biochemical techniques such as flow cytometry, surface plasmon resonance, or Bio-layer interferometry.
• Skills in informatic and computational platforms, including molecular visualisation and NGS data analysis, are advantageous.
• Highly motivated with excellent attention to detail and critical data analysis skills.
• Ability to deliver to deadlines and communicate effectively.