14101- Post-Doctoral Research Associate

The University of Edinburgh; City of Edinburgh; Presencial; GBP 34 000 - 42 000; Tempo integral

Resumo da oferta

The Institute of Genetics and Cancer at The University of Edinburgh is seeking a post-doctoral researcher to join Professor Martin Taylor’s group. The role focuses on mechanistically relating DNA damage to the mutations it generates within the Cancer Grand Challenges CAUSE program.

You will develop and apply technologies to enrich for and map DNA damage in the human genome, explore processing pathways, and work closely with international partners and a collaborative team in a dynamic research

Qualificações

• PhD in molecular biology, biochemistry or a related discipline.
• Experience in molecular biology, nucleic acid manipulation and core biochemistry techniques.
• Familiarity with high-throughput sequencing and mass spectrometry data analysis is advantageous.

Responsabilidades

• Develop and apply technologies to enrich for and map DNA damage and modifications in the human genome.
• Investigate how DNA damage is processed to result in repair, mutagenesis or damage tolerance.
• Collaborate with CAUSE partners at international institutions and participate in multidisciplinary training.
• Manage your own projects with supervision by senior researchers.

Conhecimentos

Molecular biology

Nucleic acid manipulation

Biochemistry techniques

Protein purification

Formação académica

PhD in molecular biology or biochemistry

Ferramentas

High-throughput sequencing

Mass spectrometry

Descrição da oferta de emprego

Institute of Genetics and Cancer

Full-time: 35 hours per week

Fixed term: for 24 months in the first instance

The Opportunity:

Cancer Grand Challenges – from DNA damage to the mechanisms of mutagenesis

We are looking to employ a post-doctoral researcher to join the group of Professor Martin Taylor at the Institute of Genetics and Cancer (IGC), working to understand the mechanisms that drive mutagenesis. In this post you will be a key member of the international Cancer Grand Challenges CAUSE team mechanistically relating DNA damage to the mutations it generates. This is pioneering research in a highly collaborative international team embedded within a well-supported, collegiate and enthusiastic research group.

This specific role is will drive the development and application of technologies to enrich for and map DNA damage and modifications within the human genome. You will explore how that damage is processed leading to repair, mutagenesis or damage tolerance. Within the IGC you will be co-supervised by biochemist Dr Tom Deegan.

The successful candidate will have experience in molecular biology and nucleic acid manipulation along with core biochemistry techniques including protein purification. You will have ownership of your own projects and work closely with experts in the analysis of high-throughput sequencing and mass-spectrometry data, familiarity with such platforms would be an advantage.

The post holder will have many opportunities for multidisciplinary collaborative working both within the IGC and with CAUSE partners based at the Sanger Institute, Hubrecht Institute, Harvard University, University of San Diego and University of Minnesota. The wider Cancer Grand Challenge community will also provide excellent opportunities for training, professional and network development.

Applicants must have a PhD in molecular biology, biochemistry or a related discipline for appointment at Research Associate level. Applicants close to completion of their PhDs will also be considered where experience is directly relevant. Please see the job description and person specification document associated with this advert for the full list of criteria.

This post is full-time (35 hours per week); however, we are open to considering part-time or flexible working patterns. Initially a 24-month contract is offered, with the possibility of extension.