Structural Basis of Substrate Recognition by the Glycosaminoglycan Biosynthesis Machinery

Association Bernard Gregory; Grenoble; Sur place; EUR 23 000 - 29 000; Plein temps

Résumé du poste

Association Bernard Gregory invites applications for a fully funded 3-year PhD position in the WILD team at the Institut de Biologie Structurale (IBS) in Grenoble, France. The successful candidate will explore the molecular basis of glycosaminoglycan biosynthesis, employing in vitro assays along with NMR spectroscopy and cryo-EM to investigate substrate recognition and protein interactions.

We seek a highly motivated candidate with a Master’s degree in structural biology or related field, strong

Qualifications

• Master’s degree in structural biology, protein biochemistry, or a related field.
• Hands-on experience in protein purification and characterization.
• Excellent written and oral communication skills in English.

Connaissances

English fluency

Protein purification

Biophysical techniques

Formation

Master’s degree in structural biology/biochemistry

Outils

NMR spectroscopy

Cryo-EM

Description du poste

Structural Basis of Substrate Recognition by the Glycosaminoglycan Biosynthesis Machinery

09/09/2026 Financement public/privé

Structural Basis of Substrate Recognition by the Glycosaminoglycan Biosynthesis Machinery

A fully funded 3-year PhD position is available in the WILD team at the
Institut de Biologie Structurale (IBS) in Grenoble, France. The successful
candidate will contribute to a better understanding of the molecular
mechanisms underlying glycosaminoglycan biosynthesis. Our research
combines in vitro enzymatic assays with state-of-the-art biophysical
techniques, including nuclear magnetic resonance spectroscopy and
single-particle cryo-electron microscopy, to investigate substrate specificity and protein–protein interactions of key biosynthetic enzymes.

ANR

You will join a young, dynamic, and international research team
working in an interdisciplinary environment. The Institut de Biologie
Structurale is located on the EPN campus in Grenoble and provides
excellent infrastructure for pursuing challenging structural biology
projects, as well as access to a vibrant scientific community.

We are looking for a highly motivated and team-oriented candidate with:

• A Master’s degree in structural biology, protein biochemistry, or a relatedfield.
• Strong practical experience in protein purification and characterisation.
• Previous experience in protein structure determination would be anadvantage.
• Excellent written and oral communication skills in English.