Principal Scientist Mass Spectrometry Lab

Sanofi Group; Montpellier; Sur place; EUR 54 000 - 73 000; Plein temps

Avantages offerts par ce poste

Remote work 2 days/week

31 days paid leave

Transport assistance 80%

Résumé du poste

Sanofi in Montpellier seeks a Mass Spectrometry Manager / Principal Scientist to lead the MS lab and drive analytical development for CMC projects. You will manage resources, implement HPLC/HRMS and GC/MS methods, and ensure data traceability and regulatory readiness.

The role requires 10+ years in HRMS, GMP knowledge, and a PhD in Analytical Chemistry, with English fluency and strong leadership. On-site work with remote options up to 2 days/week.

Qualifications

• 10+ years of experience in high‑resolution mass spectrometry.
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Responsabilités

• Lead the Montpellier mass spectrometry laboratory and ensure availability of modern MS equipment.
• Develop and validate LC/MS and GC/MS methods for structural elucidation and impurity quantification.
• Redact MS-related documentation for clinical and regulatory dossiers; participate in audits.
• Collaborate with Analytical Sciences and CMC teams; present findings in scientific meetings.
• Possibly manage projects as Analytical Team Lead in project teams.

Connaissances

HRMS

Mass spectrometry

GMP/ICH

Team management

Data analysis

Project coordination

LC/GC methods

English proficiency

Formation

PhD in Analytical Chemistry

Outils

Orbitrap

QTof

Triple Quad

MassLynx

Xcalibur

Chromeleon

Description du poste

Montpellier

Full time

R2813158

Job title : MASS SPECTROMETRY MANAGER / PRINCIPAL SCIENTIST

• Location: Montpellier

About the Job

As Mass Spectroscopy Manager/Principal Scientist within our Analytical Sciences team, you'll lead the mass spectrometry laboratory in support of CMC analytical development teams. Ready to get started?

Our analytical group within the synthetic platform of Global CMC Development is striving to become an industry leader in the development of transformative medicines. You'll focus on mass spectrometry characterization for structural characterization and mutagenic/nitrosamine impurities quantitation using HPLC/HRMS and GC/MS as primary techniques, while managing our state-of-the-art mass spectrometry laboratory in Montpellier.

About Sanofi:

We're an R&D-driven, AI-powered biopharma company committed to improving people's lives and delivering compelling growth. Our deep understanding of the immune system – and innovative pipeline – enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people's lives.

Main Responsibilities:

• Manage Montpellier mass spectrometry laboratory. Use resources to develop and implement HPLC/HRMS methods for the structural characterization and structural elucidation by interpretation of fragmentation mass spectra, of synthetic small molecules (active principal ingredient, impurities, and degradants) in the context of CMC development projects and analytical expertise. Manage analytical park (UPLC/HRMS and GC/MS) to insure availability of state of the art equipment, maintenance and operational qualification of equipment. Ensure the reliability and traceability of results obtained. Review analytical studies performed by mass spectrometry senior experts. Creation and management of open access MS for chemistry support

• Define and implement Sanofi strategy on nitrosamine and mutagenic impurities for Analytical Sciences and CMC development. Analytical expert in nitrosamine/mutagenic quantification by mass spectrometry, in this context develop and validate LC/MS and GC/MS based quantitation methods

• Redaction of the documentation on mass spectrometry related to structural elucidation and mutagenic/nitrosamine impurities analysis including clinical and submission dossier. Participate in regulatory audit (GQA/PAI/ANSM...) as mass spectrometry expert

• Collaborate closely with colleagues in Analytical Sciences, other CMC teams and project management teams. Participate in the scientific meetings of the different projects to bring its expertise in solving analytical problems. Make presentations within and between departments

• Could have to manage projects as Analytical Team lead in Project Team

About you

• Experience:

• Specialist in high-resolution mass spectrometry, experience of at least 10 years,

• Advanced knowledge of the principles, concepts, and practices of various aspects of Mass spectrometry for structural analysis and mutagenic/nitrosamine quantification,

• Growing knowledge of principles and concepts in analytical development.

• Sof and technical skills

• Familiarity with high performance equipment (Orbitrap, QTof, Triple Quad, etc.) and spectrometric data processing software (MassLyns, Xcalibur, Chromeleon),

• Expertise in interpreting fragmentation mass spectra (Full scan, MSn),

• GMP and Regulatory (ICH, Pharmacopoeia) knowledge related to mass spectrometry,

• Strong team management with ability to identify and develop scientific activities,

• Ability to implement new approaches to develop team members and activities (IA, Automation). You plan and prioritize resource requirements and allocations within a functional team,

• Clear communication and structured explanation skills for multi-step studies,

• Decisions making capabilities that frequently require developing new options to solve complex problems under High pressure environment and time constraints,

• Internal and external presentation skills with publications and patents experience.

• Education: PhD in Analytical Chemistry

• Languages: Fluent in English, French speaking in writing, reading and presenting

What we offer you:

A fixed salary over 12 months, supplemented by a short-term incentive, as well as a collective variable compensation based on Sanofi Group results.

Because taking care of our employees is also our mission:

• Benefits & Well-being: Quality health insurance, extended maternity/parental leave (18/14 weeks), enhanced support in case of illness, teleconsultation and second medical opinion covered by Sanofi, as well as many other wellness programs to discover here (https://jobs.sanofi.com/fr/rewards-and-benefits) .

• Work-Life Balance: 31 days of paid leave + RTT depending on your status, remote work up to 2 days/week

• Transportation: Public transport coverage up to 80%

• Savings & Retirement: Group Savings Plan and PERCOL with employer matching, and PERO

• Professional Development: Internal and international mobility opportunities, learning & development opportunities

• And more: platforms dedicated to peer-to-peer recognition & service exchanges between Sanofi employees (carpooling, home exchanges, etc.), numerous CSE benefits...

Why choose us?

• Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs.

• Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science.

• Help improve the lives of millions of people globally by making drug development quicker and more effective.

• Enjoy opportunities to collaborate beyond your area of expertise, working with diverse teams across science, clinical, and digital fields to spark new ideas and drive breakthroughs.

• Accelerate your professional development with structured career paths designed for both scientific and leadership advancement. Grow in ways you never imagined through bold moves that stretch your potential, cross moves into other business areas, and short-term gigs that build your scientific expertise.

Le contenu du poste est libellé en anglais car il nécessite de nombreuses interactions avec nos filiales à l’international, l'anglais étant la langue de travail.

This job offer is accessible to all, regardless of gender.

#LIFRA

Pursue progress , discover extraordinary

Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.

At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.

Watch our ALL IN video (https://www.youtube.com/watch?v=SkpDBZ-CJKw&t=67s) and check out our Diversity Equity and Inclusion actions at sanofi.com (https://www.sanofi.com/en/our-responsibility/equality-and-inclusiveness) !

La fourchette salariale pour ce poste est:€54400,00 - €72533

Final compensation will be determined based on demonstrated experience, skills, location, and other relevant factors. Employees may be eligible to participate in Company employee benefit programs.

We are an R&D driven, AI-powered biopharma company committed to improving people’s lives and creating compelling growth. Our team is guided by one purpose: we chase the miracles of science to improve people’s lives.

We want to build a healthier, more resilient world, and turn the impossible into the possible by discovering, developing, and delivering medicines and vaccines for millions of people around the world.

Discover more about us visiting www.sanofi.com or via our movie We are Sanofi (https://youtu.be/96EwNjb1TLo)

Start a career that makes a difference.

Reinvention is in our DNA. It’s what drove our evolution from a small French enterprise to one of the world’s leading biopharma companies. Whether it’s using AI to shorten drug-discovery times or building trust in healthcare, you could be helping our teams make life better for patients, partners, and communities.

This is where you grow your career. We open the door for you to explore new opportunities, push your limits, and connect with people who are driven by a shared purpose: we chase the miracles of science to improve people’s lives.