Principal Biologist

Aqemia.Com; Paris; Sur place; EUR 120 000 - 180 000; Plein temps

Avantages offerts par ce poste

Flexible work arrangement

Office in Paris & London

Remote days up to 2 per week

Résumé du poste

AQEMIA in Paris and London is seeking a Principal Biology expert to shape a rapidly expanding small molecule portfolio across oncology and immuno-oncology. You will work with the VP of biology and multidisciplinary teams, guiding biological strategy and CRO partnerships to advance candidates.

The role emphasizes hands-on wet-lab leadership, data-driven decision making, and cross-functional collaboration to translate science into clinical candidates within a dynamic, fast-paced environment.

Qualifications

• Ph.D. is required with strong industrial drug discovery experience.
• Experience leading biology projects from hit to candidate nomination.
• Expertise in oncology/immuno-oncology/CNS is mandatory.
• Ability to manage CROs and external partners.

Responsabilités

• Shape and drive the biology strategy across oncology programs.
• Collaborate with VP of biology and multidisciplinary teams.
• Lead and mentor lab activities and CRO collaborations.
• Identify and validate targets with clear unmet needs.
• Balance fast-paced research with data-driven decision making.

Connaissances

Drug discovery

Wet lab skills

Data-driven approach

Cross-functional collaboration

Oncology focus

Formation

Ph.D. in Biological Sciences

MSc with relevant industrial research

Outils

CRO management

Biology lab techniques

Description du poste

About AQEMIA

AQEMIA is a drug invention company dedicated to creating entirely new medicines to address major unmet medical needs. At the core of our mission is QEMI, our proprietary molecule-invention platform, which uniquely combines cutting-edge science with advanced technology. Powered by physics-based modeling, statistical mechanics, and generative AI, QEMI allows our teams to design novel drug candidates from first principles.

What makes AQEMIA different is our commitment to true innovation: our research is dedicated to the invention of new molecular entities, not the refinement of existing ones. We focus on inventing never-before-seen molecules, without relying on experimental data, and advancing them into a growing pipeline of proprietary programs and strategic partnerships with leading pharmaceutical companies.

Our most advanced preclinical programs are currently in vivo optimization, targeting diseases still waiting for effective treatments, offering our teams the opportunity to work on science that can make a real difference in people’s lives.

For more information, visit AQEMIA.com, our WTTJ Page, and our LinkedIn.

About our Team

AQEMIA brings together a diverse, multidisciplinary team of 80+ professionals based in Paris and London. Our scientists and engineers, including chemists, physicists, machine learning experts, and software engineers, work side by side to push the boundaries of early-stage drug discovery. This close collaboration across disciplines is central to our approach, enabling us to tackle complex scientific challenges from first principles and translate cutting-edge ideas into novel therapeutic candidates. At AQEMIA, team members are encouraged to contribute their expertise, learn from one another, and play an active role in shaping the future of drug invention.

Principal Biology role

Join Aqemia in a role where you will help shape our rapidly expanding portfolio of small molecule programs across diverse therapeutic areas, beginning with oncology and immuno-oncology. This is a unique chance to build a pipeline working closely with the VP of biology, and multidisciplinary teams to accelerate the discovery of clinical candidates. You’ll become part of a dedicated team focusing on providing biological support across the Aqemia portfolio. We provide an inspiring and ambitious work environment, where we are changing the way drug discovery is performed. Reporting to the VP of biology, you have a rare opportunity to impact our portfolio progression. We do not have an internal wetlab to keep agility, thus we work with leading Contract Research Organizations (CROs) for synthesis, in vitro assays, and in vivo assays.

• Driving and facilitating new drug discovery project ideas providing biological support in identifying, validating and selecting targets with clear unmet needs in disease.
• Supporting early internal innovation activities with strong molecular understanding, biological insights, and a value chain overview integrating successful projects into the Aqemia pipeline research pipeline, guiding them towards proof of concept.
• Supporting project teams with screening cascade design and maintenance.
• Interacting with external contract research organisations to identify appropriate models to deliver high quality datasets supporting project progression.
• We are looking for an objective-driven biologist who:
• Challenges themselves and others while integrating expertise from internal teams.
• Has a passion for bringing new drugs to market with a proactive and can-do attitude.
• Utilizes a data-driven and rigorous approach.
• Values team success over individual achievements and excels in concise, efficient communication.
• Education: A Ph.D. in biological sciences (such as pharmacology, chemical biology, biochemistry, molecular biology), or alternatively, a master’s degree with significant relevant industrial research experience.
• Experience: Strong background in drug discovery, with experience in transitioning projects from hit identification to candidate nomination with a particular focus in oncology, immuno-oncology or CNS.
• Preferably, 8+ years of relevant industrial experience within early drug discovery and ideation.
• Hands-on skills: Wet lab experience to effectively challenge and collaborate with CROs.
• Specialization: Experience in oncology, immuno-oncology or CNS is mandatory. A talent for driving and fostering innovation closely aligned with business strategies.
• Soft skills: The ability to thrive in a fast-paced and dynamic environment, with resilience in the face of challenges, setbacks, and ambiguity. Experience in supporting project teams in identifying risks within their projects. Experience in research project management in multidisciplinary teams in a complex stakeholder environment is an advantage.

Why Join Us

At AQEMIA, we work for a mission: joining us means having your own impact on changing the way drugs are discovered, and helping to shape the direction of our fast-growing company and team.

Expanding Drug Discovery Pipeline: Focused on critical therapeutic areas like Oncology, CNS, Immuno-inflammation… with in vivo proof of concept/patent stage programs. Collaborations with top Pharma, including a $140M Sanofi deal.

World-Class Interdisciplinary Team: work alongside exceptional talent at the intersection of technology and life sciences. Our teams combine deep expertise in AI, physics-based modeling, biology, and medicinal chemistry to push the boundaries of innovation.

DeepTech Recognition: AQEMIA is proud to be part of the French Tech 120 and France 2030, highlighting our role as a key player in Europe’s DeepTech ecosystem.

Prime Location with Flexibility: Our offices are located in the heart of Paris and London (King’s Cross), with flexible work arrangements including up to two remote days per week.

Strong Financial Backing: $100M raised from leading European and International investors