Postdoctoral Researcher (M/F) in Chemobiology

CNRS; France; Sur place; EUR 60 000 - 80 000; Plein temps

Résumé du poste

A leading research organization in France is seeking a researcher for a project focused on developing polybodies for therapeutic applications. Candidates should have a strong background in organic chemistry, proficiency in bioconjugation, and knowledge of molecular biophysics. This full-time position involves collaboration with renowned research teams and offers a dynamic, multidisciplinary environment.

Qualifications

• Solid experience in organic chemistry and bioconjugation of biomolecules.
• Proficiency in molecular characterization techniques (NMR, MS, HPLC, UV/Vis, fluorescence).
• Excellent command of English (reading and speaking comprehension, protocol and article writing).

Responsabilités

• Involved in a multidisciplinary research project on developing polybodies.
• Evaluate assemblies in in vitro applications and cell cultures.
• Explore new chemical spaces and develop multivalent molecules for therapeutic applications.

Connaissances

Organic synthesis

Bioconjugation of biomolecules

Molecular characterization techniques

Cell culture

Fluorescence microscopy

Fluorescence spectroscopy

NMR

Formation

PhD in Chemistry or related field

Outils

HPLC

MS

UV/Vis

Description du poste

Organisation/Company CNRS Department Centre de Biophysique Moléculaire Research Field Chemistry Biological sciences Pharmacological sciences Researcher Profile Recognised Researcher (R2) Country France Application Deadline 4 Dec 2025 - 23:59 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 12 Jan 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The successful candidate will be involved in a multidisciplinary research project aimed at developing polybodies – molecules with multiple recognition sites (peptides, haptamers) to target cellular receptors. These assemblies will then be evaluated in in vitro applications and in cell cultures.

• Organic synthesis and bioconjugation.
• Absorbance and fluorescence spectroscopy.
• Biophysical studies (FIDA, BLI, ITC, NMR).
• Cell culture, fluorescence microscopy, flow cytometry

The research team "Biophysics of Molecular Assemblies and Complex Systems (MACS)" is part of the CNRS UPR4301 unit "Center for Molecular Biophysics" located in Orléans. The team's interests cover a wide range of topics in the fields of synthetic chemistry and chemical biology, all grounded in molecular innovation. Our work involves the exploration of new chemical spaces as well as the development of multivalent molecules for therapeutic applications. The proposed position is part of a multidisciplinary project funded by the French National Research Agency (ANR) "Polyther," dedicated to the development of chemical/biochemical tools to combat cancer. This project is conducted in collaboration with teams at the CBM (Center for Molecular Biophysics) and a team at Université Paris-Saclay (Orsay).

Solid experience in organic chemistry and bioconjugation of biomolecules with reagents. Proficiency in molecular characterization techniques (NMR, MS, HPLC, UV/Vis, fluorescence). Good knowledge of molecular biophysics. Strong command of cell culture (cancer cells) and fluorescence microscopy. Organizational, adaptability, and innovative skills. Excellent command of English (reading and speaking comprehension, protocol and article writing). Critical review of literature