PhD in Biophysics: Active Tissue Mechanics & Microstretcher

CNRS - National Center for Scientific Research; France; On-site; EUR 24,000 - 29,000; Full time

Job summary

CNRS – Institut Lumière Matière is seeking a First Stage Researcher (R1) to study the mechanics of cellular monolayers using a novel in vitro microstretcher system. The role combines biology and physics in an interdisciplinary biophysics group with opportunities for collaboration both nationally and internationally.

You will culture cells in hydrogel microchannels, adjust tissue nematic order, image live tissue, and analyze lumen deformation and actin orientation, alongside pharmacological

Qualifications

• M2 student in physics, biophysics, mechanics, soft matter, bioengineering or related field.
• Interest in living systems and willingness to perform experimental work.
• Willingness to learn across physics and biology.

Responsibilities

• Culture cell monolayers in hydrogel microchannels and operate the microstretcher.
• Tune the initial nematic order of the tissue.
• Image the tissue live and quantify lumen deformation, cell shape and actin orientation fields, including topological defects.
• Probe biological origin of the response using pharmacological inhibitors and immunostaining.

Skills

Fluorescence microscopy

Image analysis

Soft matter

Microfluidics

Education

M2 student in physics/biophysics/mechanics/soft matter/bioengineering

Tools

Python

Job description

CNRS – Institut Lumière Matière is seeking a First Stage Researcher (R1) to study the mechanics of cellular monolayers using a novel in vitro microstretcher system. The role combines biology and physics in an interdisciplinary biophysics group with opportunities for collaboration both nationally and internationally.

You will culture cells in hydrogel microchannels, adjust tissue nematic order, image live tissue, and analyze lumen deformation and actin orientation, alongside pharmacological