PBPK Modeler Expert

PhinC Development; Massy; Sur place; EUR 50 000 - 70 000; Plein temps

Avantages offerts par ce poste

Health and life insurance

8 days of RTT and 25 days of annual leave

Participation to public transportation card

Gift cards

Preferential access to online CSE platforms

Résumé du poste

PhinC Development in Massy, France is seeking a PBPK modeling specialist to develop and validate models for preclinical and clinical data. This role involves collaboration with teams and rigorous quantitative analyses for regulatory submissions.

Candidates should have a Ph.D. in pharmaceutical sciences or a related field, with at least 2 years of postdoctoral experience. The position offers attractive compensation, remote work options, and a supportive work environment.

Qualifications

• At least 2 years of postdoctoral experience in PBPK modeling in the pharmaceutical industry.
• Experience contributing to regulatory submissions and scientific publications.
• Ability to work within multidisciplinary teams.

Responsabilités

• Develop, validate, and apply PBPK models based on preclinical and clinical data.
• Provide robust quantitative analyses to support regulatory submissions.
• Draft and review scientific reports and regulatory dossiers.

Connaissances

Postdoctoral experience in PBPK modeling

In-depth proficiency in PBPK modeling software (Gastroplus)

Understanding of regulatory requirements

Excellent written and oral communication skills in English

Formation

Ph.D. in pharmaceutical sciences or related field

Description du poste

2 years of postdoctoral experience in preclinical/translational PBPK modeling in the pharmaceutical industry or at a CRO (3-5 years of post-degree experience if holding a PharmD or master’s degree)

PhinC was founded in 2008 by four scientists and has been a pioneer in the use of modeling methods for Phase I clinical drug development. PhinC is a scientific consulting firm specializing in drug development supported by modeling approaches.

With expertise in PK/PD, PBPK, biostatistics, and regulatory strategy, our approach is based on:

• Deep learning of data: maximizing the value of all available data for robust simulations and predictions.
• Biotech Agility: adaptability, client proximity, and a culture of fast impact.
• Product Development Expertise: our models are always designed as decision‑making tools.

Based in Massy (a suburb of Paris), with a subsidiary in Montreal (Canada), PhinC works with partners around the world.

Our values

At PhinC, your professional fulfilment is our priority. We support you in developing your career within the company, where you can take on professional challenges in a respectful and friendly environment where everyone is valued.

We offer

• A stimulating environment working with innovative and diverse biotech companies.
• A close‑knit team and the opportunity to quickly advance into leadership roles
• Mentorship for young scientists and a collaborative work atmosphere.

Your role

• Develop, validate, and apply PBPK models based on preclinical and clinical data (in silico / in vitro / in vivo).
• Contribute to the design of modeling strategies in support of (pre)clinical development goals (translation, dose selection, formulation, DDI, pediatrics, special populations, etc.).
• Provide robust quantitative analyses and simulations to support regulatory submissions and interactions with agencies.
• Work closely with multidisciplinary teams: pharmacologists, clinicians, statisticians, CMC experts, etc.
• Respond to questions from regulatory agencies during the submission of modeling studies.
• Draft and review scientific reports and regulatory dossiers.
• Contribute to scientific publications and present at internal or external scientific conferences to establish our position as a thought leader

This position allows for remote work up to two days a week, in accordance with company policy.

We offer attractive compensation and benefits, health and life insurance, 8 days of RTT and 25 days of annual leave, participation to public transportation card, gift cards, and preferential access to online CSE platforms.

We are looking for

A PBPK modeling specialist capable of translating preclinical complexity into clinical predictions using quantitative approaches that are both rigorous and pragmatic. You can clearly communicate the conclusions of your models. You like to work in collaborative environments where your analyses directly influence development decisions. You understand that effective modeling requires both scientific rigor and the ability to build trust and credibility with stakeholders.

Qualifications

Preferably a Ph.D. in pharmaceutical sciences, computational biology, applied mathematics, or a related quantitative field (PharmD or master’s degree in a related field)

• At least 2 years of postdoctoral experience in preclinical/translational PBPK modeling in the pharmaceutical industry or at a CRO (3-5 years of post-degree experience if holding a PharmD or master’s degree)
• In‑depth proficiency in PBPK modeling software (Gastroplus)
• Understanding of regulatory requirements (e.g., ICH M15, ICH M12, FDA/EMA guidelines on PBPK)
• Experience contributing to regulatory submissions (EMA/FDA) and scientific publications
• Ability to make pragmatic decisions based on incomplete data
• Excellent interpersonal skills and ability to work within multidisciplinary teams
• Excellent written and oral communication skills in English