NGS Specialist

Biomemory; Paris; On-site; EUR 70,000 - 90,000; Full time

Benefits offered by this job

Flexible working hours

Additional benefits beyond French regulations

Job summary

Biomemory, a pioneering start-up in Paris, is seeking an NGS Scientist to drive advanced DNA storage technology development. In this role, you will own the end-to-end NGS workflows and collaborate across teams to define sequencing strategies and develop robust data analysis pipelines. The ideal candidate will have over 10 years of NGS experience, a strong programming background, and a PhD in a relevant field. Join us at Biomemory to shape the future of data storage!

Qualifications

• 10+ years of experience in NGS data analysis, especially with Oxford Nanopore Technology.
• Proven ability to operate at the interface of biology, data, and software engineering.
• Strong programming skills for pipeline development and custom analysis.

Responsibilities

• Own end-to-end NGS workflows from biological question to actionable data.
• Define sequencing strategies and implement new technologies.
• Collaborate closely with cross-functional teams and drive technical roadmap discussions.

Skills

NGS data analysis

Pipeline development

Molecular biology

Programming (Python, R, Bash)

Statistical analysis

Data reproducibility

Education

PhD in Bioinformatics, Computational Biology, or Biotechnology

Tools

Oxford Nanopore Technology

Job description

Biomemory, founded in 2021, boldly stands at the crossroads of Biotechnology and Computing, driven by a passion for sustainability.

We are a well-funded start-up building IT rackable equipment for Data Centers, using synthetic DNA as the storage media. While this technology is still at its infancy, these DNA Data Storage Servers target the storage of massive amount of data (Exabytes) with a very long retention life-time (> 100 years) within an attractive capex and opex budget.

Headquartered in Paris, Biomemory aims at serving the fast-growing international “cold-storage” market.

Join us in rewriting the future of data storage!

About the job

Mission

As a NGS Scientist, you will contribute to all aspects of post-writing steps until post-DNA reading sequencing. It includes DNA processing, Next-Generation Sequencing (NGS), sequencing data analysis, and pipeline development, while maintaining strong hands-on molecular biology expertise.

You will design, validate, and scale end-to-end sequencing workflows, from experimental design and wet-lab execution to robust, production-grade data analysis pipelines.

You will set scientific standards & drive technical decisions.

Main Responsibilities

NGS Strategy & End-to-End Workflow Ownership

• Own the end-to-end NGS workflows, from biological question to actionable data.
• Define sequencing strategies, by being a driving force in proposing and implementing new technologies in the field of DNA sequencing.
• Design and optimize downstream data analysis to meet R&D team requirements.
• Set acceptance criteria, controls, and quality thresholds for sequencing-based validation.
• Design, develop, and maintain robust, scalable NGS data analysis pipelines.
• Base quality filtering
• Variant detection and error profiling
• Coverage, bias, and contamination analysis
• Custom metrics tailored to experimental needs
• Ensure pipelines are reproducible, version-controlled & well-documented
• Scientific Rigor, QC and standardization
• Define and enforce scientific standards for sequencing data quality and interpretation.
• Ensure traceability, auditability, and long-term reproducibility of sequencing data
• Collaborate closely with software engineers to ensure pipeline robustness, performance, and maintainability.

Technical Mentorship

Act as a technical reference for NGS, sequencing analysis, and molecular biology.

Act as a right-hand person to the director of biotechnology, ensuring seamless collaboration

Mentor engineers and technicians on :

• Data analysis best practices

Contribute to hiring, technical interviews, and skill assessment.

Drive technical roadmap discussions related to sequencing and data reading workflow.

Cross-functional & Strategic Contribution

Work closely with:

• Molecular biology team
• Automation and process engineering
• Software and Hardware teams

Translate R&D needs into scalable, industrializable solutions.

Provide scientific input to strategic decisions, platform evolution, and technology choices.

About you

Profile

• 10+ years of experience in NGS data analysis and pipeline development, in particular with the Oxford Nanopore Technology
• Strong foundation in molecular biology.
• Proven ability to operate at the interface of biology, data, and software engineering.
• Comfortable owning complex systems end-to-end, from lab bench to production pipelines.

Education

PhD Bioinformatics, Computational Biology, Biotechnology, or related field.

Core Technical Expertise

• NGS technologies and sequencing error models
• Pipeline architecture and best practices
• Statistical analysis of sequencing data

Strong programming skills for pipeline development

(e.g. Python, R, Bash; workflow managers appreciated)

• Experience building custom analysis pipelines, not just using existing tools.
• Strong understanding of data reproducibility, versioning, and traceability.

Extensive experience with

• PCR and amplification strategies
• Library preparation workflows (in particular with Oxford Nanopore Technology)

Soft Skills

• Strong scientific judgment and decision-making under uncertainty.
• Structured, rigorous, and quality-oriented mindset.
• Ability to communicate complex technical topics to diverse audiences.
• Natural leadership
• Proactive, autonomous, and solution-driven.

Nice-to-Have / Bonus

Experience with lab automation and high-throughput sequencing workflows.

Familiarity with data platforms, or regulated environments.

Prior exposure to industrial-scale sequencing or production pipelines.

Interest in synthetic biology, DNA-based technologies, or novel sequencing applications.

Managerial experience (people and/or projects)

Good to know

The position is onsite, based at our office located at 5 Impasse Reille in Paris. The workspace combines modern classic offices with advanced laboratory rooms, designed to foster collaboration between computer scientists and biologists.

This setup supports our mission to tackle the challenges of DNA synthesis and writing, encouraging interdisciplinary teamwork and innovation.

The position is subject to French law on fixed-hour contracts ("forfait heures"), with a 39-hour working week, which offers flexibility and ensures clear expectations regarding time commitments.

Biomemory provides benefits beyond the French regulations, to support the well-being of its employees and enable them to best contribute to the success of the company.