Marie Sklodowska Curie Action - Postdoctoral individual Fellowship at IPBS-Toulouse, France (De[...]

euraxess.ec.europa.eu - Jobboard; France; Sur place; EUR 30 000 - 40 000; Plein temps

Résumé du poste

A leading research institution in France is seeking motivated postdoctoral researchers to study DNA repair mechanisms. Ideal candidates will have a PhD in a relevant field and strong experience in molecular biology. Responsibilities include investigating the association of the Ku complex with DNA double-strand breaks, as well as examining its roles in various DNA processes. This position offers a collaborative research environment and the opportunity to contribute to cutting-edge science.

Qualifications

• Strong background in molecular biology and biochemistry.
• Familiarity with DNA repair pathways and associated technologies.
• Ability to work independently and within a team.

Responsabilités

• Conduct research on mechanisms regulating DNA repair.
• Study the association of the Ku complex with DNA ends.
• Dissect regulatory processes influencing DNA repair.

Connaissances

Motivated researcher

Understanding of DNA repair mechanisms

Experience with super-resolution imaging

Knowledge of optogenetics

Formation

PhD in relevant field

Description du poste

Organisation / Company Centre National de la Recherche Scientifique Department Biology Laboratory Institute ofPharmacology and Structural Biology Is the Hosting related to staff position within a Research Infrastructure? No

The IPBS (Institute of Pharmacology and Structural Biology) is seeking motivated postdoctoral researchers to apply for Marie Skłodowska‑Curie fellowship and join our laboratory to carry out their research project.

Research topic

Mechanisms regulating the association of the main DNA repair factor Ku to DNA double‑strand breaks in human cells

The Britton team at IPBS is seeking a highly motivated postdoctoral researcher to study the mechanisms regulating the association of the Ku complex with DNA ends in human cells. Ku, a heterodimer of Ku70/Ku80, is a highly abundant nuclear complex that plays a central role in DNA double‑strand break repair by recruiting factors of the NHEJ pathway. In addition to its canonical function, emerging roles for Ku have been identified at non‑canonical DNA structures such as hairpins, cruciforms, and reversed forks. Building on the team’s recent discoveries, the project aims to further dissect the regulation of Ku association at canonical and non‑canonical DNA ends and examine the consequences of its deregulation on other DNA transactions.

Keywords: DNA repair; Chromatin; Non‑Homologous End Joining; DNA resection; Ubiquitin ligase; super‑resolution imaging; optogenetics; PARP.

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