Job offer

CRCM; France; Sur place; EUR 30 000 - 45 000; Plein temps

Résumé du poste

A leading research institution in France is seeking a junior postdoctoral fellow to join a dynamic team focused on cancer research. This two-year role involves investigating tumor microenvironment changes in colon cancer, employing advanced techniques in molecular biology and bioinformatics. Candidates should have a PhD or equivalent, along with skills such as project coordination and experience in cell culture. Proficiency in English is required. The position offers potential for significant publication opportunities in high-impact journals.

Qualifications

• Advanced knowledge in data collection and analysis.
• Experience in molecular biology and cell culture.
• Good command of English (B2 to C1).

Responsabilités

• Conduct in vitro analyses of murine and human samples.
• Characterize and co-culture various cell subtypes.
• Analyze molecular data at the single-cell level.

Connaissances

Project coordination

Managing work autonomously

Supervision of students

Team spirit

Organizational skills

Cell culture experience

Formation

PhD or equivalent

Outils

Bioinformatics

Confocal microscopy

Multiplex immunofluorescence

Description du poste

Organisation/Company CRCM Department Predictive Oncology Research Field Medical sciences » Cancer research Biological sciences » Biology Researcher Profile First Stage Researcher (R1) Positions Postdoc Positions Country France Application Deadline 27 Feb 2026 - 00:00 (Europe/Paris) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Apr 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Our team (Predictive Oncology, CRCM, U1068 Inserm FRANCE), led by Pr François Bertucci and Dr Emilie Mamessier, is seeking a junior postdoctoral fellow for a two-year contract to work on a cross-disciplinary project focused on characterizing the tumor microenvironment in colon cancer:

- At an early stage (mouse model generated in collaboration, from pre-tumor to tumor progression): characterization of microenvironmental changes of mice colon depleted of a subset of fibroblast during colon carcinogenesis.

- In treatment resistance (human model, treatment resistance, and early metastatic relapse): characterization of persister cells in early relapsers after surgery using single cell and spatial transcriptomics, patient‑derived organoids, and bioinformatics.

The project is super interesting and will require multiple skills and up‑to‑date technologies within a very supportive environment. Exciting preliminary data have already been obtained. Additional biological material is available to advance the project rapidly. The project and environment are conducive to publishing these two independent studies in high‑impact journals. Finally, the project has real prospects for clinical application.

Main activities :

• In vitro analyses of murine and human biological samples
• Cell isolation, characterization, and co‑culture of various cell subtypes
• Molecular characterization at the single‑cell level and in tissues
• Multiplexed immunofluorescence, confocal microscopy analysis, image analysis
• Bioinformatics

Affiliated activities :

• Interaction with the team's bioinformaticians
• Present and promote results and technological achievements in the form of reports, patents, publications, and oral presentations.
• Ensure and organize scientific and technological watch in your field of activity
• Ensure the quality and relevance of analytical tools and results
• Implement a quality approach
• Design educational tools

Where to apply

E‑mail [e-mail]

Requirements

Research Field Medical sciences » Cancer research Education Level PhD or equivalent

Skills/Qualifications

Knowledge :

• Data collection, analysis, and processing (advanced knowledge)
• Applied bioinformatics
• Legal and ethical guidelines
• Professional environment and networks
• Culture of the domain
• English language: B2 to C1 (Common European Framework of Reference for Languages)

Skills :

• Project coordination
• Managing your work autonomously and being proactive
• Supervision and training of students/technical staff
• Team spirit
• Organizational skills and discipline
• Availability and autonomy

Specific Requirements

• Manipulation of biological samples / experience in cell culture
• Molecular biology, spatial transcriptomics and single‑cell/single‑nuclei sequencing
• Expertise in multiplex immunofluorescence techniques and image analysis

Languages ENGLISH Level Good

Research Field Medical sciences » Cancer research Years of Research Experience None

Additional Information

Eligibility criteria

No experience after the PhD

Selection process

• Curriculum vitae, motivation letter and diploma by email
• If your profile is pre‑selected, you will be contacted for more informations or invited to an interview