Cryo-PALM Optical Instrumentation Specialist

CEA; Grenoble; On-site; EUR 42,000 - 62,000; Full time

Benefits offered by this job

Canteen/meal vouchers

Transport costs covered

Grenoble living environment

Job summary

CEA Grenoble is seeking a Researcher in Optical Instrumentation for Cryogenic Super-Resolution Microscopy (cryo-PALM). The role focuses on developing the cryo-PALM microscope, optimizing optical paths, and enabling reliable cryogenic sample transfers between fluorescence and electron microscopy within a three-year fixed-term project (ANR EPIC).

You will work with biology and cryo-EM experts, validate protocols, and contribute to the correlative cryo-PALM/cryo-ET workflow ensuring cryogenic

Qualifications

• PhD in optics, photonics, experimental physics or optical instrumentation is required.
• Hands-on experience designing, aligning and optimising optical or microscopy setups.
• Familiarity with fluorescence and super-resolution imaging and cryogenic instrumentation is a plus.
• Programming and quantitative data analysis skills are advantageous.

Responsibilities

• Develop and optimise the cryo-PALM microscope and optical paths.
• Improve illumination/ acquisition strategies for cryo-FIB lamellae and localization precision.
• Create procedures for vitrified-sample transfers keeping cryogenic conditions.
• Calibrate and assess the correlative cryo-PALM/cryo-ET workflow with other specialists.

Skills

experimental optics

photonics

optical instrumentation

microscopy

programming

data analysis

Education

PhD in optics/photonics/experimental physics/optical instrumentation

Job description

CEA Grenoble is seeking a Researcher in Optical Instrumentation for Cryogenic Super-Resolution Microscopy (cryo-PALM). The role focuses on developing the cryo-PALM microscope, optimizing optical paths, and enabling reliable cryogenic sample transfers between fluorescence and electron microscopy within a three-year fixed-term project (ANR EPIC).

You will work with biology and cryo-EM experts, validate protocols, and contribute to the correlative cryo-PALM/cryo-ET workflow ensuring cryogenic