Confocal Raman microscopy to study the relationship between bone matrix quality and bone fragil[...]

université Strasbourg; France; Sur place; EUR 40 000 - 60 000; Plein temps

Résumé du poste

A leading educational institution in France is offering an internship focused on biomedical optics. The selected candidate will analyze bone properties in relation to obesity and diabetes, utilizing Raman spectroscopy techniques. This internship provides hands-on experience in a multicenter research environment and is suitable for Master's students in relevant fields.

Qualifications

• Engineering student or Master 2 with initial laboratory internship experience.
• Motivated individual with skills in microscopy and spectroscopy techniques.

Responsabilités

• Analyze the relationship between bone mechanical properties and bone matrix structure.
• Participate in Raman spectroscopy analyses on tibia samples.
• Develop a portable Raman spectrometer prototype.

Connaissances

Microscopy techniques

Spectroscopy techniques

Raman spectroscopy

Handling murine biological samples

Formation

Master 2 in Biology-Health or Health Engineering

Description du poste

Organisation/Company université Strasbourg Department Télécom Physique Strasbourg Research Field Engineering » Biomedical engineering Researcher Profile First Stage Researcher (R1) Positions Master Positions Country France Application Deadline 12 Dec 2025 - 17:00 (UTC) Type of Contract Not Applicable Job Status Full-time Offer Starting Date 2 Feb 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The IPP team of the ICube laboratory at Strasbourg's civil hospital is offering a 5/6-month internship (starting February 2026) on the theme of "Biomedical Optics".

Background: Obesity and its complication type 2 diabetes mellitus (T2DM), whose prevalence continues to rise worldwide, are associated with exacerbated bone fragility and elevated fracture risk. Obesity and T2DM are also often associated with normal or increased bone mineral density (bone mass), suggesting that bone fragility is due to alterations in bone quality in obese/T2DM subjects. Chronic hyperglycemia can induce the formation and accumulation of advanced glycation end-products (AGEs) capable of altering bone collagen mineralization and structure, and reducing bone strength. Characterization of alterations in bone quality and structure is necessary to better assess the risk of fragility fractures associated with obesity and T2DM. In this project, researchers at ICube (Strasbourg) and MABLab (Boulogne-sur-Mer/Lille) groups have proposed a multi-scale study of bone quality in the context of fragility associated with obesity and T2DM.

Objective and methodologies: This Master 2 internship aims to analyze the relationship between bone mechanical properties and bone matrix structure in samples from obese and diabetic mice. Therefore, tibias and femurs isolated from mice made obese or diabetic in the MABLab laboratory will be used. The candidate will take part in Raman spectroscopy analyses on tibia samples. He/she will be responsible for analyzing the spectral database that will be generated in order to develop a prototype portable Raman spectrometer based on a fiber-optic probe-needle.

Candidate profile: Engineering student or Master 2 in Biology-Health/Health Engineering or equivalent, with initial laboratory internship experience. Motivated, the student will have skills in microscopy and spectroscopy techniques, ideally in Raman, and an interest in handling murine biological samples.

The internship location is at the ICube laboratory in Strasbourg, in collaboration with the MABLab laboratory in Boulogne-sur-Mer and Lille.